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7. WO2019092215 - COMPOSITION FOR THE TREATMENT OF INTRACELLULAR BACTERIAL INFECTION

Publication Number WO/2019/092215
Publication Date 16.05.2019
International Application No. PCT/EP2018/080832
International Filing Date 09.11.2018
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
7036
having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41
Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 45/06 (2006.01)
A61K 31/7036 (2006.01)
A61P 31/04 (2006.01)
A61K 41/00 (2006.01)
CPC
A61K 31/7036
A61K 38/14
A61K 41/0071
A61K 45/06
A61P 31/04
Applicants
  • PCI BIOTECH AS [NO/NO]; Ullernchausseen 64 0379 Oslo, NO
  • ACADEMISCH MEDISCH CENTRUM [NL/NL]; Meibergdreef 9 1105 AZ Amsterdam, NL
Inventors
  • HØGSET, Anders; NO
  • ZAAT, Sebastian A.J.; NL
  • ZHANG, Xiaolin; NL
Agents
  • JONES, Elizabeth Louise; GB
Priority Data
1718631.310.11.2017GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITION FOR THE TREATMENT OF INTRACELLULAR BACTERIAL INFECTION
(FR) COMPOSITION POUR LE TRAITEMENT D'UNE INFECTION BACTÉRIENNE INTRACELLULAIRE
Abstract
(EN)
The present invention provides a method of treating or preventing an intracellular bacterial infection, comprising contacting the cell(s) which are infected with an antibacterial agent and a photosensitizing agent and irradiating the cell(s) with light of a wavelength effective to activate the photosensitizing agent, wherein the antibacterial agent is released into the cytosol of the cell(s) and kills, damages or prevents the replication of bacteria in said cell(s). The invention also provides related uses, and compositions, products and kits for the same.
(FR)
La présente invention concerne une méthode de traitement ou de prévention d'une infection bactérienne intracellulaire, comprenant la mise en contact de la ou des cellules qui sont infectées par un agent antibactérien et un agent photosensibilisant et l'irradiation de la ou des cellules avec une lumière d'une longueur d'onde efficace pour activer l'agent photosensibilisant, l'agent antibactérien étant libéré dans le cytosol de la ou des cellules et tue, endommager ou empêcher la réplication de bactéries dans ladite ou lesdites cellules. L'invention concerne également des utilisations associées, et des compositions, des produits et des kits associés.
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