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1. (WO2019087115) ANTI-APOC3 ANTIBODIES AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/087115 International Application No.: PCT/IB2018/058564
Publication Date: 09.05.2019 International Filing Date: 31.10.2018
IPC:
C07K 16/18 (2006.01) ,A61K 39/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
STATEN BIOTECHNOLOGY B.V. [NL/NL]; Transistorweg 5J 6534 AT Nijmegen, NL
Inventors:
DASILVA-JARDINE, Paul; US
DE HAARD, Hans; NL
Priority Data:
62/579,44931.10.2017US
Title (EN) ANTI-APOC3 ANTIBODIES AND METHODS OF USE THEREOF
(FR) ANTICORPS ANTI-APOC3 ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The instant disclosure provides antibodies that specifically bind to ApoC3 (e.g., human ApoC3) and antagonize ApoC3 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
(FR) La présente invention concerne des anticorps qui se lient de manière spécifique à ApoC3 (par exemple, ApoC3 humain) et qui ont un effet antagoniste sur la fonction ApoC3. L'invention concerne également des préparations pharmaceutiques qui comprennent ces anticorps, des acides nucléiques codant pour ces anticorps, des vecteurs d'expression et des cellules hôtes pour fabriquer ces anticorps, et des méthodes de traitement d'un sujet à l'aide de ces anticorps.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)