Processing

Please wait...

Settings

Settings

Goto Application

1. WO2019086720 - NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS

Publication Number WO/2019/086720
Publication Date 09.05.2019
International Application No. PCT/EP2018/080367
International Filing Date 06.11.2018
IPC
C07D 495/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 5/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
A61K 31/4422 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
CPC
A61K 31/4422
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 5/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
C07D 409/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 409/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
Applicants
  • ONCOSTELLAE, S.L. [ES]/[ES]
Inventors
  • KURZ, Guido
  • CAMACHO GÓMEZ, Juan
Agents
  • CARBONELL VALLÈS, Enric
Priority Data
17382741.106.11.2017EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS
(FR) NOUVEAUX ANALOGUES UTILISÉS EN TANT QUE MODULATEURS DU RÉCEPTEUR DES ANDROGÈNES ET DU RÉCEPTEUR DES GLUCOCORTICOÏDES
Abstract
(EN) The present invention relates to novel dihydropyridine derivatives of formula (I): as modulators of nuclear receptors selected from androgen receptor and glucocorticoid receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by modulation of androgen receptor and/or glucocorticoid receptor, selected from cancer, metastasizing cancers, benign prostate hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting diseases,cachexia, Cushing's syndrome, anti-psychotic drug induced weight gain, obesity, post-traumatic stress disorder and alcoholism.
(FR) La présente invention concerne de nouveaux dérivés de dihydropyridine de formule (I) : utilisés en tant que modulateurs des récepteurs nucléaires choisis parmi le récepteur des androgènes et le récepteur des glucocorticoïdes, des procédés pour leur préparation, des compositions pharmaceutiques comprenant lesdits composés et l'utilisation desdits composés pour la fabrication d'un médicament destiné au traitement d'affections ou de maladies qui peuvent être soulagées par modulation du récepteur des androgènes et/ou du récepteur des glucocorticoïdes, choisies parmi le cancer, les cancers métastasés, l'hyperplasie bénigne de la prostate, le syndrome des ovaires polykystiques (PCOS), la perte des cheveux, l'hirsutisme, l'acné, l'hypogonadisme, des maladies amyotrophiques, la cachexie, le syndrome de Cushing, le gain de poids induit par un médicament psychotique, l'obésité, le trouble de stress post-traumatique et l'alcoolisme.
Latest bibliographic data on file with the International Bureau