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1. (WO2019085860) FGFR4 INHIBITOR AND PREPARATION METHOD THEREFOR
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/085860 International Application No.: PCT/CN2018/112419
Publication Date: 09.05.2019 International Filing Date: 29.10.2018
IPC:
C07D 471/04 (2006.01) ,A61K 31/4375 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
4375
the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
江苏豪森药业集团有限公司 JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. [CN/CN]; 中国江苏省连云港市 经济技术开发区 Economic and Technological Development Zone Lianyungang, Jiangsu 222047, CN
Inventors:
李响 LI, Xiang; CN
何雷 HE, Lei; CN
陈中科 CHEN, Zhongke; CN
呙临松 GUO, Linsong; CN
余俊 YU, Jun; CN
杜祖银 DU, Zuyin; CN
Agent:
北京戈程知识产权代理有限公司 GE CHENG & CO.,LTD.; 中国北京市 东城区东长安街1号东方广场东三办公楼19层程伟(DavidW.CHENG) David W. CHENG Level 19, Tower E3, the Towers, Oriental Plaza, No.1, East Chang An Avenue, Dongcheng District Beijing 100738, CN
Priority Data:
201711047143.831.10.2017CN
Title (EN) FGFR4 INHIBITOR AND PREPARATION METHOD THEREFOR
(FR) INHIBITEUR DE FGFR4 ET SON PROCÉDÉ DE PRÉPARATION
(ZH) FGFR4抑制剂晶型及其制备方法
Abstract:
(EN) A crystalline form of an FGFR4 inhibitor and a preparation method therefor, as well as a pharmaceutical composition containing a therapeutically effective amount of the compound and an application thereof in the treatment of cancer. The crystalline form has good stability, no hygroscopicity, good solubility, and good adaptability in a preparation production process, and can achieve good drug dissolution behavior and ensure good bioavailability of the drug in the body. Further, the crystalline form has a simple preparation process and high yield, and is suitable for industrial production.
(FR) L'invention concerne une forme cristalline d'un inhibiteur de FGFR4 et son procédé de préparation, ainsi qu'une composition pharmaceutique contenant une quantité thérapeutiquement efficace du composé et une application de celui-ci dans le traitement du cancer. La forme cristalline présente une bonne stabilité, aucune hygroscopicité, une bonne solubilité, et une bonne adaptabilité dans un procédé de production de préparation, et peut atteindre un bon comportement de dissolution de médicament et assurer une bonne biodisponibilité du médicament dans le corps. La forme cristalline a également un procédé de préparation simple et un rendement élevé, et peut être adaptée pour une production à grande échelle.
(ZH) FGFR4抑制剂的晶型及其制备方法,以及含有治疗有效量的该类化合物药物组合物和在治疗癌症的应用。晶型稳定性好、不具有引湿性,溶解度良好,在制剂生产过程中具有良好的适应性,能实现药物良好的溶出行为,确保药物在体内具有良好的生物利用度。并且晶型制备工艺简单,收率高,适合工业化生产。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)