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1. (WO2019077191) PRECISION MEDICINE FOR THE DIAGNOSIS, PROGNOSIS AND PREDICTION OF COLORECTAL CANCER
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/077191 International Application No.: PCT/ES2018/070689
Publication Date: 25.04.2019 International Filing Date: 22.10.2018
IPC:
C12Q 1/68 (2018.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
UNIVERSIDAD DE MÁLAGA [ES/ES]; Avenida Cervantes, Nº2 29071 Málaga, ES
SERVICIO ANDALUZ DE SALUD [ES/ES]; Avda. de la Constitucion, 18 41071 Sevilla, ES
FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA DE SANTIAGO DE COMPOSTELA (FIDIS) [ES/ES]; Travesa Da Choupana, S/N 15706 SANTIAGO DE COMPOSTELA, ES
SERVIZO GALEGO DE SAÚDE (SERGAS) [ES/ES]; Edificio Administrativo de San Lázaro s/n 15703 Santiago de Compostela, 15 A Coruna, ES
UNIVERSIDADE DE SANTIAGO DE COMPOSTELA [ES/ES]; Area de Valorización, Transferencia e Emprendemento. Edificio Emprendia.Campus Vida. 15782 Santiago de Compostela, ES
CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, M.P. [ES/ES]; C/Monforte de Lemos 3-5, Pabellón 11 28029 Madrid, ES
Inventors:
MACÍAS GONZÁLEZ, Manuel; ES
TINAHONES MADUEÑO, Francisco; ES
MORCILLO ESPINOSA, Sonsoles; ES
CRUJEIRAS MARTÍNEZ, Ana Belén; ES
CASANUEVA FREIJO, Felipe; ES
Agent:
FÚSTER, Gustavo; ES
Priority Data:
P20173123720.10.2017ES
Title (EN) PRECISION MEDICINE FOR THE DIAGNOSIS, PROGNOSIS AND PREDICTION OF COLORECTAL CANCER
(ES) MEDICINA DE PRECISIÓN DIRIGIDA AL DIAGNÓSTICO, PRONÓSTICO Y PREDICCIÓN DEL CÁNCER COLORRECTAL
(FR) MÉDECINE DE PRÉCISION ORIENTÉE SUR LE DIAGNOSTIC, LE PRONOSTIC ET LA PRÉDICTION DU CANCER COLORECTAL
Abstract:
(EN) The present invention belongs to the fields of molecular biology and biomedicine, and more specifically to the field of proctology in relation to the diagnosis, prognosis and treatment of colorectal cancer. An association has been established between this type of cancer and a methylation signature associated with the ZNF543 gene in possible association with ZNF397OS and/or TMEM106A in patients with different degrees of obesity, opening the possibility of new tools for diagnosis and prognosis and personalised therapies.
(ES) La presente invención pertenece al campo de la Biología molecular y la Biomedicina, y más concretamente al campo de la proctología en relación al diagnóstico, pronóstico y tratamiento del cáncer colorrectal. Se establece una asociación entre esta tipología de cáncer y una firma de metilación asociada al gen ZNF543 en posible asociación con ZNF397OS y/o TMEM106A en pacientes con diferentes grados de obesidad, abriendo las puertas a nuevas herramientas de diagnóstico, pronóstico y terapias personalizadas.
(FR) La présente invention concerne le domaine de la biologie moléculaire et de la biomédecine et, plus concrètement, le domaine de la proctologie en relation avec le diagnostic, le pronostic et le traitement du cancer colorectal. Une association est établie entre cette typologie de cancer et une signature de méthylation associée au gène ZNF543 dans une possible association avec ZNF397OS et/ou TMEM106A chez des patients présentant différents degrés d'obésité, ce qui offre des opportunités à de nouveaux outils de diagnostic, pronostic et thérapies personnalisées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)