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1. WO2019075108 - CRYSTALLINE FORMS


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2018/055279 404490074WO1
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
10 October 2018 10 October 2017
Applicant
METCALF, ANDREW T.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
This International Searching Authority found multiple inventions in this international application, as follows:
1. claims: 1-9(completely); 35-118, 121-129, 132-152, 185-202(partially)
Compound of Formula I in crystalline form, pharmaceutical compositions and medical uses thereof.
2. claims: 10-34, 153-184(completely); 35-118, 121-129, 132-152, 185-202(partially)
Compounds of Formulae II, III and IV in crystalline form, pharmaceutical compositions and medical uses thereof.
3. claims: 119, 120, 130, 131(completely); 121, 122, 124-128, 132, 133(partially)
A method of treating a subject having cancer, not involving the use of any of the compounds of Formulae I, II, III or IV.
4. claims: 185-202(partially)
Methods of treatment of RET-associated cancer, of selecting a treatment or of determining the efficacy of the treatment by determining the level of ctDNA and using the compounds of Formulae I-IV.
1.
As all required additional search fees were timely paid by the applicant, this international search report covers all searchable claims.
2.
As all searchable claims could be searched without effort justifying additional fees, this Authority did not invite payment of additional fees.
3.
As only some of the required additional search fees were timely paid by the applicant, this international search report covers only those claims for which fees were paid, specifically claims Nos.:
4.
No required additional search fees were timely paid by the applicant. Consequently, this international search report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: 1-9(completely); 35-118, 121-129, 132-152, 185-202(partially)
Remark on Protest
The additional search fees were accompanied by the applicant’s protest and, where applicable, the payment of a protest fee.
The additional search fees were accompanied by the applicant’s protest but the applicable protest fee was not paid within the time limit specified in the invitation.
No protest accompanied the payment of additional search fees.
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07D 471/04 (2006.01)i; A61P 35/00 (2006.01)i; A61K 31/437 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07D; A61P; A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS, CHEM ABS Data, EMBASE

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
US 2017096425 A1 (ANDREWS STEVEN W [US] ET AL) 06 April 2017 (2017-04-06)
1-9,35-118,121-129,132-152
cited in the application
Y
the whole document
1-9,113-118,121-129,132-152,185-202
in particular Example 740, paragraphs [0013] and [0014] and claims 42-45, 100, 113, 117, 123, 129, 141 and 151
(2)
Y
CAIRA ED - MONTCHAMP JEAN-LUC, "Crystalline Polymorphism of Organic Compounds", TOPICS IN CURRENT CHEMISTRY; [TOPICS IN CURRENT CHEMISTRY], SPRINGER, BERLIN, DE,Vol. 198, 01 January 1998 (1998-01-01), page 163-208,
XP008166276
1-9
the whole document
in particular pages 165-166
(3)
Y
EUN HEE LEE, "A practical guide to pharmaceutical polymorph screening & selection", ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,Vol. 9, No. 4, 16 March 2014 (2014-03-16), page 163-175,
XP055260946
1-9
the whole document
in particular pages 163-164 and 167-169
(4)
Y
US 2015177246 A1 (SHIBATA TATSUHIRO [JP] ET AL) 25 June 2015 (2015-06-25)
113-118,121-129,132-152
the whole document
in particular claims 3, 5, 7, 9, 11 and 13
(5)
Y
WO 2016140974 A1 (NOVENA THERAPEUTICS INC [US]) 09 September 2016 (2016-09-09)
185-202
the whole document
in particular claim 10
(6)
X,P
WO 2018136661 A1 (ANDREWS STEVEN W [US]; BLAKE JAMES F [US]; HAAS JULIA [US]; JIANG YUTO) 26 July 2018 (2018-07-26)
1-9,35-118,121-129,132-152,185-202
Y,P
the whole document
1-9,113-118,121-129,132-152,185-202
in particular paragraph [00614] last compound, paragraph [00595] and claims 24-136
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
US 2017096425 A1
06 April 2017
AU 2016291676 A1
BR 112018000808 A2
CA 2992586 A1
CL 2018000119 A1
CN 108349969 A
EA 201890318 A1
EP 3322706 A1
JP 2018532690 A
KR 20180041135 A
PH 12018500121 A1
US 2017096425 A1
US 2018179203 A1
US 2018186790 A1
US 2018186791 A1
WO 2017011776 A1
08 February 2018
04 September 2018
19 January 2017
29 June 2018
31 July 2018
31 August 2018
23 May 2018
08 November 2018
23 April 2018
23 July 2018
06 April 2017
28 June 2018
05 July 2018
05 July 2018
19 January 2017
US 2015177246 A1
25 June 2015
CN 104619841 A
EP 2878672 A1
JP WO2014017491 A1
US 2015177246 A1
WO 2014017491 A1
13 May 2015
03 June 2015
11 July 2016
25 June 2015
30 January 2014
WO 2016140974 A1
09 September 2016
NONE
WO 2018136661 A1
26 July 2018
NONE
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
29 January 2019
Date of mailing of the international search report:
01 April 2019
Authorized officer:
Papathoma, Sofia
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