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1. WO2019071162 - PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYROLIDINE DERIVATIVES

Publication Number WO/2019/071162
Publication Date 11.04.2019
International Application No. PCT/US2018/054661
International Filing Date 05.10.2018
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18
having one double bond between ring members or between a ring member and a non-ring member
22
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D 207/22 (2006.01)
CPC
C07D 207/16
Applicants
  • BIOGEN INC. [US/US]; 225 Binney Street Cambridge, MA 02142, US
Inventors
  • CHEN, Weirong; US
  • COUMING, Vinny; US
  • IRDAM, Erwin; US
  • KIESMAN, William, F.; US
  • KWOK, Daw-long, A.; US
  • MACK, Tamera, L.; US
  • OPALKA, Suzanne, M.; US
  • PATIENCE, Daniel, B.; US
  • WALKER, Donald, G.; US
  • LIANG, Wenli; US
Agents
  • HALSTEAD, David, P.; US
  • BROW, William, E.; US
  • BLOUNT, Jennifer, V.; US
  • CAI, Mi; US
  • ABELLEIRA, Susan, M.; US
Priority Data
62/568,65105.10.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYROLIDINE DERIVATIVES
(FR) PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS D'ALPHA-CARBOXAMIDE DE PYRROLIDINE
Abstract
(EN)
The invention relates to a novel process for preparing a-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
(FR)
L'invention concerne un nouveau procédé de préparation de dérivés d'α-carboxamide de pyrrolidine, notamment (2S, 5R)-5-(4-((2-fluorobenzyl)oxy) phényl)pyrrolidine-2-carboxamide, ainsi que de nouveaux intermédiaires destinés à être utilisés dans ledit procédé et des procédés de préparation desdits intermédiaires.
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