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1. WO2019071162 - PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYROLIDINE DERIVATIVES

Publication Number WO/2019/071162
Publication Date 11.04.2019
International Application No. PCT/US2018/054661
International Filing Date 05.10.2018
IPC
A61K 31/401 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
401Proline; Derivatives thereof, e.g. captopril
C07D 207/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
CPC
C07D 207/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
10with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants
  • BIOGEN INC. [US]/[US]
Inventors
  • CHEN, Weirong
  • COUMING, Vinny
  • IRDAM, Erwin
  • KIESMAN, William, F.
  • KWOK, Daw-long, A.
  • MACK, Tamera, L.
  • OPALKA, Suzanne, M.
  • PATIENCE, Daniel, B.
  • WALKER, Donald, G.
  • LIANG, Wenli
Agents
  • HALSTEAD, David, P.
  • BROW, William, E.
  • BLOUNT, Jennifer, V.
  • CAI, Mi
  • ABELLEIRA, Susan, M.
Priority Data
62/568,65105.10.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYROLIDINE DERIVATIVES
(FR) PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS D'ALPHA-CARBOXAMIDE DE PYRROLIDINE
Abstract
(EN)
The invention relates to a novel process for preparing a-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
(FR)
L'invention concerne un nouveau procédé de préparation de dérivés d'α-carboxamide de pyrrolidine, notamment (2S, 5R)-5-(4-((2-fluorobenzyl)oxy) phényl)pyrrolidine-2-carboxamide, ainsi que de nouveaux intermédiaires destinés à être utilisés dans ledit procédé et des procédés de préparation desdits intermédiaires.
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