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1. (WO2019068098) DMA-CO-TEMPO POLYMER FOR THERAPEUTIC ROS SCAVENGING
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Pub. No.: WO/2019/068098 International Application No.: PCT/US2018/053787
Publication Date: 04.04.2019 International Filing Date: 01.10.2018
IPC:
A61K 38/44 (2006.01) ,A61K 38/43 (2006.01) ,A61K 45/00 (2006.01) ,A61P 19/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
44
Oxidoreductases (1)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
Applicants:
VANDERBILT UNIVERSITY [US/US]; 305 Kirkland Hall Nashville, Tennessee 37240, US
Inventors:
DUVALL, Craig L.; US
KAVANAUGH, Taylor; US
DAILING, Eric; US
DOLLINGER, Bryan; US
DEJULIUS, Carlisle; US
Agent:
RITCHIE, Sean P.; US
DECKER, Mandy Wilson; US
HAEBERLIN, Jeffrey A.; US
HAYNE, James R.; US
MYERS JR., Richard S.; US
NAGLE JR., David W.; US
WEYER, Stephen J.; US
WRIGHT, Terry L.; US
Priority Data:
62/565,92129.09.2017US
Title (EN) DMA-CO-TEMPO POLYMER FOR THERAPEUTIC ROS SCAVENGING
(FR) POLYMÈRE DMA-CO-TEMPO POUR PIÉGEAGE THÉRAPEUTIQUE D'ESPÈCES RÉACTIVES DE L'OXYGÈNE (ERO)
Abstract:
(EN) Provided herein are a reactive oxygen species (ROS) scavenging composition, a method of forming a ROS scavenging composition, and a method of treating a subject having a (ROS) perpetuated disease. The ROS scavenging composition includes a co-polymer of a hydrophilic monomer and a grafting monomer, and a ROS scavenging compound grafted to the grafting monomer. The method of forming a ROS scavenging composition includes forming a co-polymer of a hydrophilic monomer and a grafting monomer, and grafting ROS scavenging compound onto the co-polymer. The method of treating a subject having a ROS perpetuated disease includes administering a therapeutically effective amount of an ROS scavenging composition comprising a co-polymer of a hydrophilic monomer and a grafting monomer, and a ROS scavenging compound grafted to the grafting monomer, to the subject in need thereof.
(FR) L'invention concerne une composition de piégeage d'espèces réactives de l'oxygène (ERO), un procédé de formation d'une composition de piégeage d’ERO, et une méthode de traitement d'un sujet ayant une maladie perpétuée par ERO. La composition de piégeage d’ERO comprend un copolymère d'un monomère hydrophile et d'un monomère de greffage, et un composé de piégeage d’ERO greffé sur le monomère de greffage. Le procédé de formation d'une composition de piégeage d’ERO comprend la formation d'un copolymère d'un monomère hydrophile et d'un monomère de greffage, et le greffage d'un composé de piégeage d’ERO sur le co-polymère. Le procédé de traitement d'un sujet ayant une maladie perpétuelle de ROS comprend l'administration d'une quantité thérapeutiquement efficace d'une composition de piégeage de ROS comprenant un copolymère d'un monomère hydrophile et d'un monomère de greffage, et un composé de piégeage de ROS greffé sur le monomère de greffage, au sujet en ayant besoin.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)