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1. (WO2019068087) SYSTEM OF PREDICTION OF RESPONSE TO CANCER THERAPY AND METHODS OF USING THE SAME
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Pub. No.: WO/2019/068087 International Application No.: PCT/US2018/053751
Publication Date: 04.04.2019 International Filing Date: 01.10.2018
IPC:
C07K 16/28 (2006.01) ,A61K 39/00 (2006.01) ,G01N 33/574 (2006.01) ,C12N 5/0783 (2010.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
Applicants:
UNIVERSITY OF MARYLAND, COLLEGE PARK [US/US]; Office of Technology Commercialization 2130 Mitchell Building 7999 Regents Drive College Park, MD 20742, US
Inventors:
RUPPIN, Eytan; US
AUSLANDER, Noam; US
Agent:
ZURAWSKI, John, A.; US
CHERKASOV, Vadim; US
METZ, Felicia; US
CIARDI, Joseph, A.; US
KRIKELIS, Basil; US
Priority Data:
62/565,33829.09.2017US
62/719,90620.08.2018US
Title (EN) SYSTEM OF PREDICTION OF RESPONSE TO CANCER THERAPY AND METHODS OF USING THE SAME
(FR) SYSTÈME DE PRÉDICTION DE RÉPONSE À UNE THÉRAPIE ANTICANCÉREUSE ET SES MÉTHODES D'UTILISATION
Abstract:
(EN) The disclosure comprises methods for predicting therapy responsiveness in subjects or populations of subjects affected by cancer. The disclosure relates to methods of predicting the likely effect of melanoma treatments or combination of treatments based upon protein expression of immunostimulatory molecules. Software to execute the steps disclosed here and computer-implemented methods are also disclosed.
(FR) La présente invention concerne des méthodes de prédiction de la réactivité à une thérapie chez des sujets ou des populations de sujets atteints d'un cancer. L'invention concerne des méthodes de prédiction de l'effet probable de traitements du mélanome ou d'une combinaison de traitements sur la base de l'expression de protéines de molécules immunostimulatrices. L'invention concerne également un logiciel destiné à exécuter les étapes décrites dans la description ainsi que des procédés mis en œuvre par ordinateur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)