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1. (WO2019068066) METHODS AND COMPOSITIONS ENHANCING SURVIVAL AND FUNCTIONALITY OF ANTI-TUMOR AND ANTI-VIRAL T CELLS
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Pub. No.: WO/2019/068066 International Application No.: PCT/US2018/053692
Publication Date: 04.04.2019 International Filing Date: 01.10.2018
IPC:
A61K 39/395 (2006.01) ,A61P 1/16 (2006.01) ,A61P 35/00 (2006.01) ,C07K 14/705 (2006.01) ,C07K 14/725 (2006.01) ,C07K 19/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
725
T-cell receptors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
Applicants:
NATIONAL HEALTH RESEARCH INSTITUTES [CN/CN]; 35, Keyan Road Zhunan Town, Miaoli County, 35053, TW
YUH, Chiou Hwa [US/US]; US (CL)
Inventors:
HUANG, Li-Rung; TW
HSU, Shu-Ching; TW
Agent:
CANFIELD, Floyd E.; US
Priority Data:
62/565,82029.09.2017US
Title (EN) METHODS AND COMPOSITIONS ENHANCING SURVIVAL AND FUNCTIONALITY OF ANTI-TUMOR AND ANTI-VIRAL T CELLS
(FR) MÉTHODES ET COMPOSITIONS PERMETTANT D'AMÉLIORER LA SURVIE ET LA FONCTIONNALITÉ DE LYMPHOCYTES T ANTI-TUMORAUX ET ANTI-VIRAUX
Abstract:
(EN) The present invention relates to a method able to enhance survival and functionality of anti-tumor or anti-viral immune cells through overexpression of Akt molecules in the cells. Akt signaling prevented the expression of immune checkpoints and therefore rescued antigen-specific cytotoxic T lymphocytes from exhaustion in immunosuppressive microenvironment. This present invention also demostrated that AKT genes have the potential to be utilized in T-cell engineering of adoptive T-cell therapy for treatment of chronic viral infection and malignancies
(FR) La présente invention concerne une méthode permettant d'améliorer la survie et la fonctionnalité de cellules immunitaires anti-tumorales ou anti-virales par la surexpression de molécules Akt dans les cellules. La signalisation Akt empêche l'expression de points de contrôle immunitaires et, par conséquent, de lymphocytes T cytotoxiques spécifiques à un antigène sauvé de l'épuisement dans un microenvironnement immunosuppresseur. La présente invention démontre également que les gènes Akt ont le potentiel d'être utilisés dans l'ingénierie des lymphocytes T d'une thérapie adoptive par des lymphocytes T pour le traitement d'une infection virale chronique et de malignités.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)