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1. (WO2019068045) TWO-DIMENSIONAL AND THREE-DIMENSIONAL FIXED Z SCANNING
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Pub. No.: WO/2019/068045 International Application No.: PCT/US2018/053639
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
G02B 21/00 (2006.01) ,G01B 9/00 (2006.01) ,G01B 11/24 (2006.01) ,G06K 9/20 (2006.01) ,G06K 9/28 (2006.01)
G PHYSICS
02
OPTICS
B
OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21
Microscopes
G PHYSICS
01
MEASURING; TESTING
B
MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
9
Instruments as specified in the subgroups and characterised by the use of optical measuring means
G PHYSICS
01
MEASURING; TESTING
B
MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
11
Measuring arrangements characterised by the use of optical means
24
for measuring contours or curvatures
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
K
RECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9
Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
20
Image acquisition
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
K
RECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9
Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
20
Image acquisition
28
using discrete sensing elements at predetermined points
Applicants:
LEICA BIOSYSTEMS IMAGING, INC. [US/US]; 1360 Park Center Drive Vista, California 92081, US
Inventors:
ZOU, Yunlu; US
NAJMABADI, Peyman; US
Agent:
CHENG, Jonathan D.; US
RAWLINS, Pattric J.; US
Priority Data:
62/566,17829.09.2017US
Title (EN) TWO-DIMENSIONAL AND THREE-DIMENSIONAL FIXED Z SCANNING
(FR) BALAYAGE EN Z FIXE EN DEUX ET TROIS DIMENSIONS
Abstract:
(EN) Apparatus and methods for scanning a 2D or 3D image of a specimen without relative Z-axis motion between the specimen and the objective lens. In an embodiment, the apparatus includes a tilted camera having individual lines of pixels. Each line of pixels can be separately processed and is at a different image plane with respect to the stage. The depth of field of each line of pixels abuts, slightly overlaps, or is slightly spaced apart from the adjacent lines of pixels in the tilted camera. The angle of the tilt determines the relationship (abut, overlapping, or spaced) of the adjacent lines of pixels. The individual image lines produced by each line of pixels can be combined into a 3D volume image of a sample. Also, the highest-contrast line at each X-Y location can be combined into an in-focus 2D image of the sample.
(FR) La présente invention concerne un appareil et des procédés permettant de balayer une image 2D ou 3D d'un échantillon sans mouvement d'axe Z relatif entre l'échantillon et la lentille d'objectif. Selon un mode de réalisation, l'appareil comprend une caméra inclinée dotée de lignes individuelles de pixels. Chaque ligne de pixels peut être traitée séparément et se trouve dans un plan d'image différent par rapport à la platine. La profondeur de champ de chaque ligne de pixels vient en butée, chevauche légèrement ou est légèrement espacée par rapport aux lignes adjacentes de pixels dans la caméra inclinée. L'angle d'inclinaison détermine la relation (en butée, en chevauchement ou espacée) des lignes de pixels adjacentes. Les lignes d'image individuelles produites par chaque ligne de pixels peuvent être combinées en une image de volume 3D d'un échantillon. De plus, la ligne de contraste la plus élevée à chaque emplacement X-Y peut être combinée en une image 2D nette de l'échantillon.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)