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1. (WO2019068043) REAL-TIME AUTOFOCUS SCANNING
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Pub. No.: WO/2019/068043 International Application No.: PCT/US2018/053637
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
G02B 7/28 (2006.01) ,G01B 9/04 (2006.01) ,G01B 11/24 (2006.01) ,G02B 21/00 (2006.01) ,G06K 9/20 (2006.01) ,G06K 9/28 (2006.01)
G PHYSICS
02
OPTICS
B
OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
7
Mountings, adjusting means, or light-tight connections, for optical elements
28
Systems for automatic generation of focusing signals
G PHYSICS
01
MEASURING; TESTING
B
MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
9
Instruments as specified in the subgroups and characterised by the use of optical measuring means
04
Measuring microscopes
G PHYSICS
01
MEASURING; TESTING
B
MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
11
Measuring arrangements characterised by the use of optical means
24
for measuring contours or curvatures
G PHYSICS
02
OPTICS
B
OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21
Microscopes
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
K
RECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9
Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
20
Image acquisition
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
K
RECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9
Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
20
Image acquisition
28
using discrete sensing elements at predetermined points
Applicants:
LEICA BIOSYSTEMS IMAGING, INC. [US/US]; 1360 Park Center Drive Vista, California 92081, US
Inventors:
CHEN, Leng-Chun; US
OLSON, Allen; US
ZOU, Yunlu; US
NAJMABADI, Peyman; US
CRANDALL, Greg; US
Agent:
CHENG, Jonathan D.; US
RAWLINS, Pattric J.; US
Priority Data:
62/566,15529.09.2017US
Title (EN) REAL-TIME AUTOFOCUS SCANNING
(FR) BALAYAGE DE MISE AU POINT AUTOMATIQUE EN TEMPS RÉEL
Abstract:
(EN) Real-time autofocus. In an embodiment, a scanning apparatus includes an imaging sensor, a focusing sensor, an objective lens, and processor(s) configured to analyze image data captured by the imaging and focusing sensors, and move the objective lens. Real-time autofocus during scanning of a sample is achieved by determining a true-Z value for the objective lens for a point on a sample and for each of a plurality of regions on the sample. The true -Z values and/or surfaces calculated therefrom are used to determine a predicted-Z value for an unscanned region of the sample. The objective lens is adjusted to the predicted-Z value at the beginning of the unscanned region. After scanning the region, a true-Z value is determined for the region and compared to the predicted-Z value. A rescan of the region is initiated if the comparison exceeds a predetermined threshold.
(FR) L'invention concerne la mise au point automatique en temps réel. Dans un mode de réalisation, un appareil de balayage comprend un capteur d'imagerie, un capteur de mise au point, une lentille d'objectif, et un ou plusieurs processeurs conçus pour analyser des données d'image capturées par les capteurs d'imagerie et de mise au point, et pour déplacer la lentille d'objectif. La mise au point automatique en temps réel pendant le balayage d'un échantillon est obtenue par détermination d'une valeur Z réelle pour la lentille d'objectif pour un point sur un échantillon et pour chaque région parmi une pluralité de régions sur l'échantillon. Les valeurs Z réelles et/ou les surfaces calculées à partir de celles-ci sont utilisées pour déterminer une valeur Z prédite pour une région non balayée de l'échantillon. La lentille d'objectif est ajustée à la valeur Z prédite au début de la région non balayée. Après balayage de la région, une valeur Z réelle est déterminée pour la région et est comparée à la valeur Z prédite. Un re-balayage de la région est lancé si la comparaison dépasse un seuil prédéfini.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)