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1. (WO2019067977) USE OF SENOLYTIC AGENTS TO ELIMINATE PERSISTENT HIV RESERVOIRS
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Pub. No.: WO/2019/067977 International Application No.: PCT/US2018/053541
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
A61K 31/4725 (2006.01) ,A61K 31/473 (2006.01) ,A61K 49/00 (2006.01) ,A61K 31/00 (2006.01) ,A61K 31/635 (2006.01) ,A61K 31/665 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
472
Non-condensed isoquinolines, e.g. papaverine
4725
containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
473
ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
63
Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide
635
having a heterocyclic ring, e.g. sulfasalazine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
665
having oxygen as a ring hetero atom, e.g. fosfomycin
Applicants:
THE GEORGE WASHINGTON UNIVERSITY [US/US]; Rice Hall, Suite 501 2121 I Street, NW Washington, District of Columbia 20052, US
Inventors:
JONES, R. Brad; US
HUANG, John; US
REN, Yanqin; US
Agent:
LONGSWORTH, Gaby, L.; US
BEZOS, Salvador M.; US
BODENSTEIN, Matthew; US
CALVO, Paul A.; US
CAMARCE, Christian; US
CIMBALA, Michele A.; US
COLLER III, Richard D.; US
CONKLIN, Kyle; US
CORNWELL, David K.S.; US
COVERT, John M.; US
DURKIN, Tracy-Gene G.; US
EISENBERG, Jason D.; US
ELLISON, Eldora L.; US
ESMOND, Robert W.; US
FEATHERSTONE, Donald J.; US
FRUEAUF, Jeremiah B.; US
GAJEWSKI, Daniel; US
GILLENTINE, Marsha Rose; US
GOLDSTEIN, Jorge A.; US
GORDON, Lori A.; US
HELVEY, Jeffrey T.; US
HICKS, Ross; US
HOLOUBEK, Michelle K.; US
JACKMAN, Peter A.; US
KIM, Ji-Eun; US
LEE, Michael Q.; US
LONGSWORTH, Gaby L.; US
MILLONIG, Robert C.; US
MUTSCHELKNAUS, Joseph; US
NANNENGA-COMBS, Bonnie; US
RAY, Michael B.; US
RYGIEL, Mark W.; US
SHEA JR., Timothy J.; US
SOKOHL, Robert E.; US
SPECHT, Michael D.; US
STEFFE, Eric K.; US
STERLING, Deborah A.; US
STERNE, Robert Greene; US
VARUGHESE, Dennies; US
WRIGHT, Jon E.; US
POWERS III, R. Wilson; US
BANOWIT, Donald R.; US
DESAI, Nirav N.; US
PICKARD, Byron L.; US
TUMINARO, Jonathan; US
YONAN, Daniel E.; US
Priority Data:
62/565,40629.09.2017US
Title (EN) USE OF SENOLYTIC AGENTS TO ELIMINATE PERSISTENT HIV RESERVOIRS
(FR) UTILISATION D'AGENTS SENOLYTIQUES POUR ÉLIMINER DES RÉSERVOIRS DE VIH PERSISTANTS
Abstract:
(EN) The present disclosure provides methods of reducing or eliminating HIV reservoirs in a human infected with HIV, comprising administering to the human a therapeutically effective amount of a Bcl-2 family inhibitor and one or more additional agents. Additional agents include a therapeutically effective amount of a latency reversing agent, a therapeutically effective vaccine which enhances CTL responses, an immunotherapy which enhances CTL responses, a therapeutically effective vaccine which enhances CD8+ T-cell responses, an immunotherapy which enhances CD8+ T-cell responses, a CTL, or a CD8+ T-cell.
(FR) La présente invention concerne des procédés de réduction ou d'élimination de réservoirs de VIH chez un être humain infecté par le VIH, comprenant l'administration à l'être humain d'une quantité thérapeutiquement efficace d'un inhibiteur de la famille Bcl-2 et d'un ou plusieurs agents supplémentaires. Les agents supplémentaires comprennent une quantité thérapeutiquement efficace d'un agent d'inversion de latence, un vaccin thérapeutiquement efficace qui améliore les réponses CTL, une immunothérapie qui améliore les réponses CTL, un vaccin thérapeutiquement efficace qui améliore les réponses des lymphocytes T CD8+, une immunothérapie qui améliore les réponses des lymphocytes T CD8+, un CTL ou un lymphocyte T CD8+.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)