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1. (WO2019067955) COMPOSITIONS AND METHODS FOR REGULATING LET-7 MICRO RNA TARGETS
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Pub. No.: WO/2019/067955 International Application No.: PCT/US2018/053511
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
A61K 31/4741 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4738
ortho- or peri-condensed with heterocyclic ring systems
4741
condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, Twelfth Floor Oakland, CA 94607-5200, US
Inventors:
ROOS, Martina; US
LOWRY, William, E.; US
Agent:
HALSTEAD, David, P.; US
ABELLERIA, Susan, M.; US
BROW, William, E.; US
BLOUNT, Jennifer, V.; US
AKHIEZER, Alexander; US
Priority Data:
62/566,05429.09.2017US
Title (EN) COMPOSITIONS AND METHODS FOR REGULATING LET-7 MICRO RNA TARGETS
(FR) COMPOSITIONS ET MÉTHODES DE RÉGULATION DE CIBLES DE MICRO-ARN LET-7
Abstract:
(EN) The present disclosure relates to compounds that are capable of suppressing let-7 targets, inhibiting phosphodiesterase, stimulating cAMP, and inhibiting growth activity of cancer cells. The disclosure further relates to methods of treating cancers.
(FR) La présente invention concerne des composés qui sont capables de supprimer les cibles de let-7, d'inhiber la phosphodiestérase, de stimuler cAMP et d'inhiber l'activité de croissance de cellules cancéreuses. L'invention concerne également des méthodes de traitement du cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)