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1. (WO2019067915) METHOD OF MAKING A VACCINE
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Pub. No.: WO/2019/067915 International Application No.: PCT/US2018/053445
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
C12N 1/36 (2006.01) ,A61K 39/12 (2006.01) ,A61K 39/245 (2006.01) ,A61K 39/02 (2006.01) ,C12N 7/00 (2006.01) ,A61N 5/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
36
Adaptation or attenuation of cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
245
Herpetoviridae, e.g. herpes simplex virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
N
ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5
Radiation therapy
Applicants:
HYPER LIGHT TECHNOLOGIES, LLC [US/US]; 111 West Church Street Nashville, NC 27856, US
Inventors:
GARRETT, Kurt A.; US
Agent:
PASSE, James G.; US
Priority Data:
15/720,33629.09.2017US
16/145,96228.09.2018US
Title (EN) METHOD OF MAKING A VACCINE
(FR) PROCÉDÉ DE FABRICATION D'UN VACCIN
Abstract:
(EN) The disclosure provides a method of producing attenuated cells for a mammalian vaccine comprising killing or attenuating the cells with a high energy, low heat UV light. Specifically, the disclosure provides a method of producing attenuated infectious cells comprising: a) isolating a plurality of infectious cells; b) selecting a high energy UV light source that delivers a low heat UV containing light to the end of a light guide; and c) exposing the infectious cells to the light from the end of the light guide at sufficient distance and time to kill the cells without damaging cellular proteins and carbohydrates that produce the immune response to produce attenuated cells. Further provided are high energy and low heat UV light sources and methods of producing vaccines comprising attenuated infectious cells.
(FR) L'invention concerne un procédé de production de cellules atténuées pour un vaccin pour mammifère, comprenant la provocation de la mort ou l'atténuation des cellules avec une lumière UV à haute énergie et faible chaleur. Plus précisément, l'invention concerne un procédé de production de cellules infectieuses atténuées, comprenant : a) l'isolement d'une pluralité de cellules infectieuses ; b) la sélection d'une source de lumière UV à haute énergie qui délivre une lumière contenant des UV à faible chaleur à l'extrémité d'un guide de lumière ; et c) l'exposition des cellules infectieuses à la lumière provenant de l'extrémité du guide de lumière à une distance et pendant un temps suffisants pour tuer les cellules sans endommager les protéines cellulaires et les glucides qui produisent la réponse immunitaire, pour produire des cellules atténuées. L'invention concerne en outre des sources de lumière UV à haute énergie et faible chaleur et des procédés de production de vaccins comprenant des cellules infectieuses atténuées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)