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1. (WO2019067884) MOLECULAR GRAFTING OF COMPLEX, BROADLY NEUTRALIZING ANTIBODY EPITOPES
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Pub. No.: WO/2019/067884 International Application No.: PCT/US2018/053402
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
A61K 39/12 (2006.01) ,A61K 39/145 (2006.01) ,A61K 39/295 (2006.01) ,C07K 14/005 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
145
Orthomyxoviridae, e.g. influenza virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
295
Polyvalent viral antigens; Mixtures of viral and bacterial antigens
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
Applicants:
THE CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 55 Shattuck Street Boston, Massachusetts 02115, US
Inventors:
SCHMIDT, Aaron G.; US
BAJIC, Goran; US
MARON, Max J.; US
Agent:
RESNICK, David, S.; US
Priority Data:
62/564,77528.09.2017US
Title (EN) MOLECULAR GRAFTING OF COMPLEX, BROADLY NEUTRALIZING ANTIBODY EPITOPES
(FR) GREFFAGE MOLÉCULAIRE D'ÉPITOPES D'ANTICORPS COMPLEXES LARGEMENT NEUTRALISANTS
Abstract:
(EN) Described herein is a chimeric epitope comprising (a) a conserved donor receptor binding site (RBS) or a neutralizing epitope, or a functional fraction thereof, and (b) an acceptor molecular scaffold or fragment thereof. Another aspect provides a chimeric epitope comprising (a) a conserved donor receptor binding site (RBS) derived from circulating H1 influenza, and (b) an acceptor molecular scaffold derived from non-circulating influenza. Further, compositions and methods for inducing an immune response and vaccination are described herein.
(FR) L'invention concerne un épitope chimérique comprenant (a) un site de liaison au récepteur (RBS) donneur conservé ou un épitope neutralisant, ou une fraction fonctionnelle correspondante, et (b) un échafaudage moléculaire accepteur ou un fragment correspondant. Un autre aspect concerne un épitope chimérique comprenant (a) un site de liaison au récepteur (RBS) donneur conservé dérivé de virus Influenza H1 circulants, et (b) un échafaudage moléculaire accepteur dérivé de virus Influenza non circulants. En outre, l'invention concerne des compositions et des méthodes permettant d'induire une réponse immunitaire et une vaccination.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)