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1. (WO2019067843) PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2018/053322 REL-004WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
28 September 2018 29 September 2017
Applicant
RELAY THERAPEUTICS, INC.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS

5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.

Disclosed herein are novel compounds of formula (I) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds ad compositions of the disclosure.


6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07D 487/04 (2006.01)i; A61P 3/00 (2006.01)i; A61P 35/00 (2006.01)i; A61P 7/00 (2006.01)i; A61K 31/4985 (2006.01)i; C07D 519/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07D; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, CHEM ABS Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
A
WO 2016203404 A1 (NOVARTIS AG [CH]; BAGDANOFF JEFFREY T [US]; CHEN ZHUOLIANG [US]; DORE) 22 December 2016 (2016-12-22)
1-45
claims; table 1
(2)
A
JORGE GARCIA FORTANET ET AL, "Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor", JOURNAL OF MEDICINAL CHEMISTRY,Vol. 59, No. 17, 12 July 2016 (2016-07-12), page 7773-7782,
XP055520685
1-45
the whole document
(3)
A
SHEN, JIAYI; LI, XIAOKAI; ZHANG, ZHANG; LUO, JINGFENG; LONG, HUOYOU; TU, ZHENGCHAO; ZHOU, XIAOPING; DING, KE; LU, XIAOYUN, "3-Aminopyrazolopyrazine derivatives as spleen tyrosine kinase inhibitors", CHEMICAL BIOLOGY & DRUG DESIGN,Vol. 88, No. 5, 2016, page 690-698,
XP002786631
1-45
the whole document
(4)
A,P
WO 2018057884 A1 (RELAY THERAPEUTICS INC [US]; DE SHAW RES LLC [US]) 29 March 2018 (2018-03-29)
1-45
claims; examples
(5)
A,P
WO 2018081091 A1 (RELAY THERAPEUTICS INC [US]; DE SHAW RES LLC [US]) 03 May 2018 (2018-05-03)
1-45
claims; examples
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2016203404 A1
22 December 2016
EP 3310779 A1
WO 2016203404 A1
25 April 2018
22 December 2016
WO 2018057884 A1
29 March 2018
NONE
WO 2018081091 A1
03 May 2018
TW 201819386 A
WO 2018081091 A1
01 June 2018
03 May 2018
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
20 November 2018
Date of mailing of the international search report:
21 December 2018
Authorized officer:
Gavriliu, Daniela
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