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1. (WO2019067815) A NEUROTOXIN-LIKE TOXIN AND USES THEREOF
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Pub. No.: WO/2019/067815 International Application No.: PCT/US2018/053262
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
A61K 38/48 (2006.01) ,C07K 14/33 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
48
acting on peptide bonds (3.4)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
33
from Clostridium (G)
Applicants:
STENMARK, Paul [SE/SE]; SE
CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 55 Shattuck Street Boston, MA 02115, US
Inventors:
STENMARK, Paul; SE
DONG, Min; US
ZHANG, Sicai; US
Agent:
GE, Zhiyun; US
Priority Data:
62/566,17129.09.2017US
Title (EN) A NEUROTOXIN-LIKE TOXIN AND USES THEREOF
(FR) TOXINE DE TYPE NEUROTOXINE ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) Provided herein is a novel homolog of Clostridial Botulinum neurotoxin (BoNT) identified in the bacterial species Enterococcus faecium (BoNT/EN). BoNT/EN variants and chimeric toxins comprising domains from BoNT/EN and other BoNTs are also provided. Further provided herein are methods of producing BoNT/EN and its use, e.g., in therapeutic applications.
(FR) La présente invention concerne un nouvel homologue de neurotoxine botulique clostridienne (BoNT) identifié chez l'espèce bactérienne Enterococcus Faecium (BoNT/EN). L'invention concerne également des variants de BoNT/EN et des toxines chimériques comprenant des domaines de BoNT/EN et d'autres BoNT. L'invention concerne en outre des procédés de production de BoNT/EN et son utilisation, par exemple, dans des applications thérapeutiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)