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1. (WO2019067792) TUMOR SUPPRESSION USING HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER (PINK) CELLS IN COMBINATION WITH AN ANTIBODY
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Pub. No.: WO/2019/067792 International Application No.: PCT/US2018/053233
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
A61K 35/17 (2015.01) ,A61K 35/50 (2015.01) ,A61K 39/395 (2006.01) ,A61K 9/00 (2006.01) ,A61P 35/00 (2006.01)
[IPC code unknown for A61K 35/17]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
48
Reproductive organs; Embryos
50
Placenta; Amniotic fluid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
CELULARITY, INC. [US/US]; 33 Technology Drive Warren, New Jersey 07059, US
Inventors:
ZHANG, Xiaokui; US
KANG, Lin; US
HARIRI, Robert J.; US
Agent:
KNUDSEN, Geoffry T.; US
Priority Data:
62/564,73528.09.2017US
Title (EN) TUMOR SUPPRESSION USING HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER (PINK) CELLS IN COMBINATION WITH AN ANTIBODY
(FR) SUPPRESSION DE TUMEUR À L'AIDE DE CELLULES TUEUSES NATURELLES INTERMÉDIAIRES DÉRIVÉES DU PLACENTA HUMAIN (PINK) EN COMBINAISON AVEC UN ANTICORPS
Abstract:
(EN) Provided herein are methods of suppressing the growth or proliferation of tumor cells and methods of treating individuals having tumor cells using placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer (PINK) cells, combined natural killer (NK) cells, or combinations thereof, in combination with an antibody (e.g., anti-disialoganglioside (anti-GD2) antibody). Also provided herein are compositions comprising placental perfusate, placental perfusate cells, PINK cells, combined NK cells, or combinations thereof, in combination with an antibody (e.g., anti-GD2 antibody).
(FR) L'invention concerne des procédés de suppression de la croissance ou de la prolifération de cellules tumorales et des procédés de traitement d'individus ayant des cellules tumorales à l'aide d'un perfusat placentaire, de cellules de perfusat placentaire, de cellules tueuses naturelles intermédiaires dérivées du placenta (PINK), de cellules tueuses naturelles combinées (NK), ou des combinaisons de celles-ci, en combinaison avec un anticorps (par exemple, un anticorps anti-disialoganglioside (anti-GD2)). L'invention concerne également des compositions comprenant un perfusat placentaire, des cellules de perfusat placentaire, des cellules PINK, des cellules NK combinées, ou des combinaisons de celles-ci, en combinaison avec un anticorps (par exemple, un anticorps anti-GD2).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)