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1. (WO2019067789) METHOD FOR TREATING COMPLICATIONS RELATED TO ACUTE OR CHRONIC HYPERGLYCEMIA
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Pub. No.: WO/2019/067789 International Application No.: PCT/US2018/053227
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
A61P 3/08 (2006.01) ,A61P 3/10 (2006.01) ,C07K 14/525 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
525
Tumour necrosis factor (TNF)
Applicants:
DE SOUSA RODRIGUES, Maria Elizabeth [US/US]; US
TANSEY, Malu G. [US/US]; US
BARNUM, Christopher J. [US/US]; US
TESI, Raymond J. [US/US]; US
Inventors:
DE SOUSA RODRIGUES, Maria Elizabeth; US
TANSEY, Malu G.; US
BARNUM, Christopher J.; US
TESI, Raymond J.; US
Agent:
SCHOONOVER, Joshua S.; US
Priority Data:
62/564,23227.09.2017US
62/735,77424.09.2018US
Title (EN) METHOD FOR TREATING COMPLICATIONS RELATED TO ACUTE OR CHRONIC HYPERGLYCEMIA
(FR) PROCÉDÉ DE TRAITEMENT DE COMPLICATIONS LIÉES À L'HYPERGLYCÉMIE AIGUË OU CHRONIQUE
Abstract:
(EN) The disclosure concerns a method of treating complications of acute or chronic hyperglycemia and/or diet-induced obesity comprising: (i) determining whether a patient suffers from complications related to acute or chronic hyperglycemia and/or diet induced obesity, and if so, (ii) administering to the patient in need thereof a selective inhibitor of soluble TNF-α but not transmembrane TNF-α. For purposes herein, complications of acute or chronic hyperglycemia and/or diet-induced obesity include: diabetes mellitus, insulin resistance, hepatic steatosis, non-alcoholic hepatic steatosis, fibrotic liver disease, vascular disease, and chronic intestinal inflammation.
(FR) L'invention concerne un procédé de traitement de complications de l'hyperglycémie aiguë ou chronique et/ou de l'obésité induite par le régime alimentaire comprenant les étapes consistant à : (i) déterminer si un patient souffre de complications liées à l'hyperglycémie aiguë ou chronique et/ou à l'obésité induite par le régime alimentaire, et si tel est le cas, (ii) administrer, au patient qui en a besoin, un inhibiteur sélectif de TNF-α soluble mais pas de TNF-α transmembranaire. Aux fins de la présente invention, les complications de l'hyperglycémie aiguë ou chronique et/ou de l'obésité induite par le régime alimentaire comprennent : le diabète sucré, la résistance à l'insuline, la stéatose hépatique, la stéatose hépatique non alcoolique, la maladie hépatique fibreuse, la maladie vasculaire et l'inflammation intestinale chronique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)