Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019067782) COMBINATION TREATMENT FOR NEUROPSYCHIATRIC DISORDERS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/067782 International Application No.: PCT/US2018/053217
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
A61K 31/05 (2006.01) ,A61K 31/395 (2006.01) ,A61K 31/495 (2006.01) ,C07D 475/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05
Phenols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
475
Heterocyclic compounds containing pteridine ring systems
02
with an oxygen atom directly attached in position 4
04
with a nitrogen atom directly attached in position 2
Applicants:
UNIVERSITY OF MASSACHUSETTS [US/US]; One Beacon Street, 31st Floor Boston, MA 02108, US
Inventors:
FAN, Xiaoduo; US
Agent:
HOWERTON, Thomas, C.; US
KELLY, Gibert, Thomson; US
CARROLL, Peter, G.; US
HAMDAN, Maha, A.; US
Priority Data:
62/564,64228.09.2017US
Title (EN) COMBINATION TREATMENT FOR NEUROPSYCHIATRIC DISORDERS
(FR) TRAITEMENT COMBINÉ DES TROUBLES NEUROPSYCHIATRIQUES
Abstract:
(EN) Given its various activities in the brain, nitric oxide (NO) has been associated with various neuropsychiatric diseases and/or neuropsychiatric disorders, including schizophrenia. In fact, evidence has been accumulating to show that abnormalities in NO levels are associated with schizophrenia. Among a number of NO's neural mechanisms associated with schizophrenia, its role as a second messenger of NMDA receptor activation, which interacts with both dopaminergic and serotonergic pathways, has been of particular focus. It demonstrated herein that a combined administration of nitric oxide synthase substrates and co-factors display antineuropsychiatric activity and cognitive benefit by re-establishing homeostatic nitric oxide production.
(FR) Étant donné ses diverses activités dans le cerveau, l'oxyde nitrique (NO) a été associé à diverses maladies neuropsychiatriques et/ou troubles neuropsychiatriques, y compris la schizophrénie. En effet, les preuves se sont accumulées pour montrer que des anomalies des taux de NO sont associées à la schizophrénie. Parmi un certain nombre de mécanismes neuronaux du NO associés à la schizophrénie, son rôle en tant que second messager de l'activation du récepteur NMDA, qui interagit à la fois avec les voies dopaminergiques et sérotoninergiques, a fait l'objet d'une attention particulière. Il a été démontré dans la présente invention qu'une administration combinée de substrats et de co-facteurs d'oxyde nitrique synthase présente une activité anti-neuropsychiatrique et un bénéfice cognitif en rétablissant la production d'oxyde nitrique homéostatique.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)