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1. (WO2019067771) COMPOSITIONS AND METHODS FOR TREATING SEPTIC CARDIOMYOPATHY
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Pub. No.: WO/2019/067771 International Application No.: PCT/US2018/053199
Publication Date: 04.04.2019 International Filing Date: 19.10.2018
IPC:
A61K 31/05 (2006.01) ,A61K 31/365 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05
Phenols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
365
Lactones
Applicants:
UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street Suite 200 Philadelphia, 19104, US
Inventors:
CHRISTOFIDOU-SOLOMIDOU, Melpo; US
Agent:
COHEN, Mark; Pearl Cohen Zedek Latzer Baratz LLP 1500 Broadway, 12th Floor New York, New York 10036, US
COHEN, Mark; US
Priority Data:
62/564,17327.09.2017US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING SEPTIC CARDIOMYOPATHY
(FR) COMPOSITIONS ET PROCÉDÉS POUR TRAITER LA CARDIOMYOPATHIE SEPTIQUE
Abstract:
(EN) Methods and compositions are provided for treating sepsis-associated cardiac dysfunction, specifically sepsis-induced cardiomyopathy, and for protecting the heart from sepsis-associated dysfunction and improving cardiac function in subjects having sepsis. These methods include administering compositions comprising secoisolariciresinol diglucoside (SDG) or related compounds, obtained from natural sources, such as flaxseed, or generated synthetically.
(FR) L'invention concerne des procédés et des compositions pour traiter un dysfonctionnement cardiaque associé à une sepsie, spécifiquement une cardiomyopathie induite par une sepsie, et pour protéger le cœur contre un dysfonctionnement associé à la sepsie et améliorer la fonction cardiaque chez des sujets présentant une sepsie. Ces procédés comprennent l'administration de compositions comprenant du séco-isolaricirésinol diglucoside (SDG) ou des composés apparentés, obtenus à partir de sources naturelles, telles que des graines de lin, ou produits par synthèse.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)