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1. (WO2019067770) IMMUNOMODULATORY FUSION PROTEINS
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Pub. No.: WO/2019/067770 International Application No.: PCT/US2018/053197
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
C07K 19/00 (2006.01) ,C07K 14/715 (2006.01) ,A61K 38/16 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
715
for cytokines; for lymphokines; for interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
EPICENTRX, INC. [US/US]; 11099 North Torrey Pines Road Suite 160 La Jolla, CA 92037, US
Inventors:
LARSON, Christopher; US
REID, Tony, R.; US
ORONSKY, Bryan, T.; US
Agent:
DAVENPORT, Andrew, M.; US
ARGENTIERI, Steven, R.; US
BUCHMAN, Joshua, J.; US
SHOVON, Ashraf; US
BRODOWSKI, Michael; US
Priority Data:
62/564,14527.09.2017US
Title (EN) IMMUNOMODULATORY FUSION PROTEINS
(FR) PROTÉINES DE FUSION IMMUNOMODULATRICES
Abstract:
(EN) Provided is a fusion protein, e.g., a cytokine receptor fusion protein, e.g., an IL-10 trap, with a novel linker sequence to permit the fusion protein to functionally optimally, e.g., to permit a cytokine receptor portion of a cytokine receptor fusion protein to bind optimally to its target cytokine. The fusion protein, or an expression vector encoding for the fusion proteins, can be used to treat cell proliferative diseases and disorders, including certain forms of cancer and inflammatory disorders.
(FR) L'invention concerne une protéine de fusion, par exemple une protéine de fusion de récepteur de cytokine, par exemple un piège IL-10, avec une nouvelle séquence de lieur permettant à la protéine de fusion de fonctionner de manière optimale, par exemple permettant à une partie de récepteur de cytokine d'une protéine de fusion de récepteur de cytokine de se lier de manière optimale à sa cytokine cible. La protéine de fusion ou un vecteur d'expression codant pour les protéines de fusion peuvent être utilisés pour traiter des maladies et des troubles prolifératifs cellulaires, notamment certaines formes de cancer et de troubles inflammatoires.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)