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1. (WO2019067733) COMPOUNDS AND METHODS OF MODULATING PROTEIN DEGRADATION
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Pub. No.: WO/2019/067733 International Application No.: PCT/US2018/053146
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
C07K 14/00 (2006.01) ,C07K 14/47 (2006.01) ,G01N 33/542 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
536
with immune complex formed in liquid phase
542
with steric inhibition or signal modification, e.g. fluorescent quenching
Applicants:
VIVIDION THERAPEUTICS, INC. [US/US]; 230 Nassau Street Princeton, New Jersey 08542, US
Inventors:
PATRICELLI, Matthew; US
STAMOS, Dean; US
SIMON, Gabe; US
HORNING, Benjamin; US
Agent:
ZHANG, ADRIANNA P.; WILSON SONSINI GOODRICH & ROSATI 650 Page Mill Road Palo Alto, California 94304, US
Priority Data:
62/564,18427.09.2017US
Title (EN) COMPOUNDS AND METHODS OF MODULATING PROTEIN DEGRADATION
(FR) COMPOSÉS ET PROCÉDÉS DE MODULATION DE LA DÉGRADATION PROTÉIQUE
Abstract:
(EN) Disclosed herein are protein-probe adducts and synthetic ligands that inhibit protein-probe adduct formation, in which the protein is part of the E3 ligase complex and the protein is modified to alter the substrate recognition of the E3 ligase complex. In some instances, also provided herein are protein-probe adducts and synthetic ligands that inhibit protein-probe adduct formation, in which the protein is modified or tagged for degradation. In some instances, additionally provided herein are cysteine-containing protein binding domains that interact with a probe and/or a ligand described herein.
(FR) L'invention concerne des adduits de protéines-sondes et des ligands de synthèse qui inhibent la formation des adduits de protéines-sondes, la protéine faisant partie du complexe de ligase E3 et celle-ci étant manipulée pour modifier la reconnaissance de substrat du complexe de ligase E3. Dans certains cas, l'invention concerne également des adduits de protéines-sondes et des ligands de synthèse qui inhibent la formation des adduits de protéines-sondes, la protéine étant modifiée ou marquée pour une dégradation. Dans certains cas, l'invention concerne en outre des domaines de liaison à des protéines contenant de la cystéine qui interagissent avec une sonde et/ou un ligand selon l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)