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1. (WO2019067729) USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTION
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Pub. No.: WO/2019/067729 International Application No.: PCT/US2018/053139
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
A61K 31/7032 (2006.01) ,A61K 9/00 (2006.01) ,A23L 33/105 (2016.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7032
attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyl-diacylglycerides, lactobionic acid, gangliosides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
[IPC code unknown for A23L 33/105]
Applicants:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200 Philadelphia, Pennsylvania 19104, US
Inventors:
CHRISTOFIDOU-SOLOMIDOU, Melpo; US
Agent:
COHEN, Mark; US
Priority Data:
62/564,15327.09.2017US
Title (EN) USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTION
(FR) UTILISATION DE DIGLUCOSIDES DE SÉCOÏSOLARICIRÉSINOL (SDG) ET COMPOSÉS APPARENTÉS DANS LA PROTECTION CONTRE LES DYSFONCTIONNEMENTS CARDIOVASCULAIRES INDUITS PAR RAYONNEMENTS
Abstract:
(EN) The invention relates to the use of secoisolariciresinol diglucoside (SDG), obtained from natural sources, such as flaxseed, or generated synthetically (synthetic SDG is also referred to herein as LGM2605), other active components in flaxseed, secoisolariciresinol (SECO), enterodiol (ED), and enterolactone (EL), as well as stereoisomers of the foregoing, metabolites of the foregoing, degradants of the foregoing, and analogs of the foregoing, to treat and protect cardiac and vascular tissues, for example, treating ionizing radiation-associated vascular injury and vasculopathy and protecting vascular tissue against ionizing radiation exposure.
(FR) La présente invention concerne l'utilisation de sécoisolaricirésinol diglucoside (SDG), obtenu à partir de sources naturelles, telles que des graines de lin, ou générés de manière synthétique (SDG synthétique est également appelé LGM2605), d'autres composants actifs dans des graines de lin, du sécoisolaricirésinol (SECO), de l'entérodiol (ED) et de l'entérolactone (EL), ainsi que des stéréo-isomères des précédents, des métabolites des précédents, des agents de dégradation des précédents, et des analogues des précédents, pour traiter et protéger des tissus cardiaques et vasculaires, par exemple, pour traiter une lésion vasculaire associée à un rayonnement ionisant et une vascularopathie et protéger un tissu vasculaire contre une exposition à un rayonnement ionisant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)