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1. (WO2019067702) SMALL MOLECULE INHIBITORS OF GALECTIN-3
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Pub. No.: WO/2019/067702 International Application No.: PCT/US2018/053094
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
C07D 403/14 (2006.01) ,A61K 31/4196 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/428 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
428
condensed with carbocyclic rings
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543, US
Inventors:
JALAGAM, Prasada Rao; IN
NAIR, Satheesh Kesavan; IN
PANDA, Manoranjan; IN
FENG, Jianxin; US
WANG, Wei; US
LIU, Chunjian; US
ELLSWORTH, Bruce A.; US
SARABU, Ramakanth; IN
SWIDORSKI, Jacob; US
HARTZ, Richard, A.; US
XU, Li; US
YOON, David S.; US
BENO, Brett R.; US
REGUEIRO-REN, Alicia; US
Agent:
EPPERSON, James; US
BELLOMY, Gregory R.; US
CHAO, Yuan; US
CLAUSS, Isabelle M.; US
COULTER, Kathryn; US
DELAUNEY, Ashton J.; US
FARQUHARSON-TORRES, Serena; US
GOLIAN, Paul D.; US
GREENBLATT, Gary D.; US
GUO, Z. Angela; US
HADAD, Henry; US
HAI, Bing; US
HAN, Bo; US
JACOBSEN, Barry H.; US
KORSEN, Elliott; US
LAUB, Friedrich; US
LIU, Hong; US
MINGO, Pamela A.; US
PARLET, Nickki L.; US
SUN, Jing G.; US
VANATTEN, Mary K.; US
VOM WEGE, Julia; US
WALSH, Brian J.; US
Priority Data:
62/563,73227.09.2017US
Title (EN) SMALL MOLECULE INHIBITORS OF GALECTIN-3
(FR) INHIBITEURS À PETITES MOLÉCULES DE GALECTINE-3
Abstract:
(EN) The present disclosure relates to compounds of formula I, which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
(FR) La présente invention concerne des composés de formule I qui sont des inhibiteurs de Gal-3, et qui comprennent des sels pharmaceutiquement acceptables, des compositions contenant de tels composés, et des procédés d'utilisation et de fabrication de tels composés et compositions.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)