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1. (WO2019067696) METHODS AND COMPOSITIONS FOR INHIBITION OF STAT3
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Pub. No.: WO/2019/067696 International Application No.: PCT/US2018/053085
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
A61K 31/122 (2006.01) ,A61K 31/428 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
122
having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
428
condensed with carbocyclic rings
Applicants:
OHIO STATE INNOVATION FOUNDATION [US/US]; 1524 North High Street Columbus, Ohio 43201, US
Inventors:
YANG, Yuhong; US
LI, Chenglong; US
RACKE, Michael; US
Agent:
TIMMER, Richard T.; US
Priority Data:
62/563,84927.09.2017US
Title (EN) METHODS AND COMPOSITIONS FOR INHIBITION OF STAT3
(FR) MÉTHODES ET COMPOSITIONS POUR L'INHIBITION DE STAT3
Abstract:
(EN) In one aspect, the disclosure relates to prodrug compositions of a STAT inhibitor compound. In some aspects, the STAT is STAT3. Disclosed are pharmaceutical compositions comprising the prodrug inhibitors of STAT. In various aspects, the prodrug inhibitors of STAT can be used in methods of treating an inflammatory disorder, including multiple sclerosis, or a disorder of uncontrolled cellular proliferation, such as a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
(FR) Selon un aspect, l'invention concerne des compositions promédicaments d'un composé inhibiteur de STAT. Selon certains aspects, le STAT est le STAT3. L'invention concerne également des compositions pharmaceutiques comprenant les inhibiteurs promédicaments de STAT. Selon divers aspects, les inhibiteurs promédicaments de STAT peuvent être utilisés dans des méthodes de traitement d'un trouble inflammatoire, notamment de la sclérose en plaques, ou d'un trouble de prolifération cellulaire incontrôlée, tel qu'un cancer. Cet abrégé est destiné à servir d'outil d'exploration à des fins de recherche dans l'état de l'art particulier correspondant et n'est pas destiné à limiter la portée de la présente invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)