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1. (WO2019067681) METHOD OF PRODUCING THIN ENZYME-BASED SENSING LAYERS ON PLANAR SENSORS
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Pub. No.: WO/2019/067681 International Application No.: PCT/US2018/053061
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
G01N 27/327 (2006.01) ,A61B 5/145 (2006.01) ,C12Q 1/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26
by investigating electrochemical variables; by using electrolysis or electrophoresis
28
Electrolytic cell components
30
Electrodes, e.g. test electrodes; Half-cells
327
Biochemical electrodes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
145
Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
Applicants:
CALIFORNIA INSTITUTE OF TECHNOLOGY [US/US]; 1200 E California Blvd., M/C 6-32 Pasadena, California 91125, US
Inventors:
CHEN, Samson; US
SCHERER, Axel; US
Agent:
STEINFL, Alessandro; US
BRUNO, Enrica; US
CASH, Brian J.; US
PEREZ, Ronald E.; US
DONG, Lun-Cong; US
XU, Jiancong; US
BRAMIAN, Tony; US
Priority Data:
62/564,91428.09.2017US
Title (EN) METHOD OF PRODUCING THIN ENZYME-BASED SENSING LAYERS ON PLANAR SENSORS
(FR) PROCÉDÉ DE PRODUCTION DE COUCHES DE DÉTECTION MINCES À BASE D'ENZYME SUR DES CAPTEURS PLANS
Abstract:
(EN) A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
(FR) Cette invention concerne un capteur implanté dans des tissus et comprenant une couche de détection fabriquée par mélange de l'enzyme de transduction de signal avec des composants non réactifs dont des sels tampons et des charges, et par centrifugation de l'enzyme sur un substrat. L'enzyme de transduction de signal est réticulée par introduction du substrat ainsi revêtu dans une chambre à vide. Dans la chambre, l'agent de réticulation s'évapore et se dépose sur l'enzyme, pour réticuler ainsi l'enzyme.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)