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1. (WO2019067621) COMPOSITIONS AND METHODS OF A CRISPR GENETIC SYSTEM TO SENSITIZE AND/OR ELIMINATE TARGET BACTERIA
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Pub. No.: WO/2019/067621 International Application No.: PCT/US2018/052962
Publication Date: 04.04.2019 International Filing Date: 26.09.2018
IPC:
C12N 15/113 (2010.01) ,C12N 9/22 (2006.01) ,A61K 31/7088 (2006.01) ,A61P 31/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
22
Ribonucleases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
NEXTBIOTICS, INC. [US/US]; 1612 Walnut Street Berkeley, California 94709, US
Inventors:
BARDALES, Jorge; US
SAENZ, Maricel; US
Agent:
CHRISTIANSEN, William T.; US
LAHERTY, Carol D.; US
MILLER, Katherine J.; US
Priority Data:
62/563,56626.09.2017US
62/666,63403.05.2018US
Title (EN) COMPOSITIONS AND METHODS OF A CRISPR GENETIC SYSTEM TO SENSITIZE AND/OR ELIMINATE TARGET BACTERIA
(FR) COMPOSITIONS ET PROCÉDÉS D'UN SYSTÈME GÉNÉTIQUE CRISPR POUR SENSIBILISER ET/OU ÉLIMINER DES BACTÉRIES CIBLES
Abstract:
(EN) Disclosed are compositions comprising nucleotide sequence, a vector or a phagemid comprising (a) a sequence encoding a DNA binding domain and (b) a sequence encoding a nuclease or nuclease domain, wherein the DNA binding domain specifically targets a sequence of a bacterial genome or a sequence of a bacterial plasmid and wherein the nuclease or nuclease domain induces at least one break in the sequence of the bacterial genome. In certain embodiments, the compositions comprises a Type V CRISPR construct. The disclosure further provides methods of making and using these compositions.
(FR) L'invention concerne des compositions comprenant une séquence de nucléotides, un vecteur ou un phagémide comprenant (a) une séquence codant pour un domaine de liaison à l'ADN et (b) une séquence codant pour une nucléase ou un domaine nucléasique, où le domaine de liaison à l'ADN cible spécifiquement une séquence d'un génome bactérien ou une séquence d'un plasmide bactérien et où la nucléase ou le domaine nucléasique induit au moins une rupture dans la séquence du génome bactérien. Dans certains modes de réalisation, les compositions comprennent une construction CRISPR de type V. Des procédés de préparation et d'utilisation desdites compositions sont en outre décrits.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)