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1. (WO2019067594) SALTS OF PYRROLOTRIAZINE DERIVATIVES USEFUL AS TAM INHIBITORS
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Pub. No.: WO/2019/067594 International Application No.: PCT/US2018/052925
Publication Date: 04.04.2019 International Filing Date: 26.09.2018
IPC:
C07D 487/04 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/53 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
Applicants:
INCYTE CORPORATION [US/US]; 1801 Augustine Cut-Off Wilmington, Delaware 19803, US
Inventors:
JIA, Zhongjiang; US
WU, Yongzhong; US
PAN, Yongchun; US
ZHOU, Jiacheng; US
LI, Qun; US
Agent:
KARNAS, Elizabeth T.; US
GODDARD, Christine A.; US
Priority Data:
62/564,07027.09.2017US
62/714,19603.08.2018US
Title (EN) SALTS OF PYRROLOTRIAZINE DERIVATIVES USEFUL AS TAM INHIBITORS
(FR) SELS DE DÉRIVÉS DE PYRROLOTRIAZINE UTILES EN TANT QU'INHIBITEURS DE TAM
Abstract:
(EN) The present application provides salt forms of N-(4-(4-Amino-7-(1- isobutyrylpiperidin-4-yl)pyrrolo[1,2-f][1,2,4]triazin-5-yl)phenyl)-1- isopropyl-2,4-dioxo-3-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine-5- carboxamide (I) and N-(4-(4-Amino-7-(1-isobutyrylpiperidin-4-yl) pyrrolo[1,2-f][1,2,4]triazin-5-yl)phenyl)-1-isopropyl-2,4-dioxo-3- phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide (II), which are useful as inhibitors of TAM kinases, as well as processes and intermediates related thereto.
(FR) La présente invention concerne des formes de sel de N-(4-(4-Amino-7-(1- isobutyrylpipéridin-4-yl)pyrrolo[1,2-f][1,2,4]triazin-5-yl)phényl)-1- isopropyl-2,4-dioxo-3-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine-5- carboxamide (I) et de N-(4-(4-Amino-7-(1-isobutyrylpipéridin-4-yl) pyrrolo[1,2-f][1,2,4]triazin-5-yl)phényl)-1-isopropyl-2,4-dioxo-3- phényl-1,2,3,4-tetrahydropyrimidine-5-carboxamide (II), qui sont utiles en tant qu'inhibiteurs de kinases TAM, ainsi que des procédés et des intermédiaires associés à celles-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)