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1. (WO2019067503) NOVEL USP7 INHIBITORS FOR TREATING MULTIPLE MYELOMA
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Pub. No.: WO/2019/067503 International Application No.: PCT/US2018/052797
Publication Date: 04.04.2019 International Filing Date: 26.09.2018
IPC:
A61K 31/44 (2006.01) ,A61K 31/4436 (2006.01) ,A61K 31/4439 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4436
containing a heterocyclic ring having sulfur as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
Applicants:
DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 450 Brookline Avenue Boston, MA 02215-5450, US
Inventors:
BUHRLAGE, Sara; US
ANDERSON, Kenneth, C.; US
CHAUHAN, Dharminder; US
DHE-PAGANON, Sirano; US
LIU, Xiaoxi; US
SEO, Hyuk-Soo; US
Agent:
SMITH, DeAnn, F.; US
AKHIEZER, Alexander; US
BLOUNT, Jennifer, V.; US
BROW, William, E.; US
ABELLEIRA, Susan, M.; US
Priority Data:
62/563,37526.09.2017US
Title (EN) NOVEL USP7 INHIBITORS FOR TREATING MULTIPLE MYELOMA
(FR) NOUVEAUX INHIBITEURS D'USP7 POUR LE TRAITEMENT DU MYÉLOME MULTIPLE
Abstract:
(EN) The present disclosure relates to inhibitors of USP7 useful in the treatment of and other USP7 mediated diseases, having the Formula: wherein R1, R2, R3, R4, R5, R 6, and n are described herein.
(FR) La présente invention concerne des inhibiteurs d'USP7 utiles dans le traitement de maladies médiées par USP7 et d'autres maladies, ayant la formule : R1, R2, R3, R4, R5, R 6, et n étant décrits dans la description.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)