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1. (WO2019067498) PEPTIDE ANTIBIOTIC COMPLEXES AND METHODS OF USE THEREOF
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Pub. No.: WO/2019/067498 International Application No.: PCT/US2018/052791
Publication Date: 04.04.2019 International Filing Date: 26.09.2018
IPC:
C07K 14/81 (2006.01) ,A61K 38/07 (2006.01) ,A61K 38/55 (2006.01) ,C07K 5/02 (2006.01) ,C07K 5/10 (2006.01) ,C07K 5/11 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81
Protease inhibitors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
07
Tetrapeptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55
Protease inhibitors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02
containing at least one abnormal peptide link
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
10
Tetrapeptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
10
Tetrapeptides
11
the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
Applicants:
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US
Inventors:
SMITH, Peter Andrew; US
MURRAY, Jeremy Mark; US
KOEHLER, Michael Friedrich Thomas; US
HEISE, Christopher E.; US
Agent:
HALL, Robert C.; US
ACKERMAN, Lily J.; US
AUSENHUS, Scott L.; US
BERENDT, Frank JN; US
BUCKWALTER, Brian L.; US
CHANG, Y. Elaine; US
CHI, I. Shannon; US
CLARK, Kevin M.; US
COBURN, Cara M.; US
COLANTONIO, Jessica R.; US
CRISSEY, Todd M.; US
CUI, Steven; US
DAVIS, Jennifer L.; US
DREGER, Ginger R.; US
DUFFIELD, Jonathan J.; US
FANG, Carol A.; US
GHOSE, Shameek; US
HEIDER, Julie A.; US
HILL, Laurie L.; US
JOHNSTON, Sean A.; US
KAFKA, Mark D.; US
KALE, Tamara A.; US
KALINOWSKI, Grant E.; US
LEE, Wendy M.; US
LI, Qianru; US
MARSCHANG, Diane L.; US
MCCLELLAN, Kelly B.; US
RICHARDSON, Jessica L.; US
ROPP, Traci H.; US
SCHWARTZ, Timothy R.; US
SCOTT, Derek B.; US
SHERMAN, Daniel E.; US
SHOLTZ, Charles; US
TAN, Anna M.; US
TIAN, Zong-Qiang Bill; US
WAIS, Rebecca J.; US
YEUNG, Bonny G.; US
Priority Data:
62/566,12529.09.2017US
Title (EN) PEPTIDE ANTIBIOTIC COMPLEXES AND METHODS OF USE THEREOF
(FR) COMPLEXES D'ANTIBIOTIQUES PEPTIDIQUES ET LEURS MÉTHODES D'UTILISATION
Abstract:
(EN) Provided herein are compounds that form covalent bonds with peptidases, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SPase), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
(FR) La présente invention concerne des composés qui forment des liaisons covalentes avec des peptidases, les composés ayant, dans certaines formes de réalisation, une bioactivité à large spectre. Dans divers modes de réalisation, les composés agissent par inhibition de la peptidase signal de type 1 bactérienne (SPase), qui est une protéine essentielle de ces bactéries. L'invention concerne également des compositions pharmaceutiques et des méthodes de traitement à l'aide des composés décrits dans la présente invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)