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1. (WO2019067458) COMPOSITIONS AND METHODS FOR CHANNELOPATHY DISORDERS-TARGETING FLUID MOVEMENT ACROSS MEMBRANES
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Pub. No.: WO/2019/067458 International Application No.: PCT/US2018/052689
Publication Date: 04.04.2019 International Filing Date: 25.09.2018
IPC:
C07C 235/64 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
42
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
44
with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
58
with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho- position to carbon atoms of the same non-condensed six-membered aromatic ring
64
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
Applicants:
DEHA, LLC [US/US]; 865 Research Parkway, Suite 417 Oklahoma City, OK 73104, US
Inventors:
SRIPATHIRATHAN, Kumar; US
KUMAR, Adhya; US
Agent:
CHALKER, Daniel, J.; US
Priority Data:
62/563,43426.09.2017US
Title (EN) COMPOSITIONS AND METHODS FOR CHANNELOPATHY DISORDERS-TARGETING FLUID MOVEMENT ACROSS MEMBRANES
(FR) COMPOSITIONS ET PROCÉDÉS POUR MOUVEMENT FLUIDIQUE CIBLANT DES TROUBLES DE CANALOPATHIE À TRAVERS DES MEMBRANES
Abstract:
(EN) The present invention includes composition and methods for treating stroke comprising: identifying a subject in need of treatment for a stroke; and providing the subject with a therapeutically effective amount of an Aquaporin-4 inhibitor that blocks a filter portion of an Aquaporin-4 channel region, and identifying modulators of the different aquaporin specific splice variants.
(FR) La présente invention concerne une composition et des méthodes de traitement d'un accident vasculaire cérébral consistant à : identifier un sujet en ayant besoin d'un traitement pour un accident vasculaire cérébral ; et fournir au sujet une quantité efficace sur le plan thérapeutique d'un inhibiteur de l'aquaporine-4 qui bloque une partie du filtre d'une région de canal d'aquaporine-4, et identifier des modulateurs des différents variants d'épissage spécifiques de l'aquaporine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)