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1. (WO2019067425) COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE VIA REDIRECTED T CELL IMMUNOTHERAPIES
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Pub. No.: WO/2019/067425 International Application No.: PCT/US2018/052605
Publication Date: 04.04.2019 International Filing Date: 25.09.2018
IPC:
A61K 31/7088 (2006.01) ,A61K 35/14 (2015.01) ,A61K 35/76 (2015.01) ,C12N 5/10 (2006.01) ,C07K 16/40 (2006.01) ,C07K 19/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
76
Viruses
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
Applicants:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200 Philadelphia, Pennsylvania 19104, US
Inventors:
EPSTEIN, Jonathan; US
AGHAJANIAN, Haig; US
Agent:
DOYLE, Kathryn; US
LANDRY, Brian; US
SILVA, Domingos J.; US
SIMPSON, Mark D.; US
MANAS, Michael; US
PLEHN-DUJOWICH, Debora; US
CROTTY, Justin; US
YOUNG, Jacque; US
Priority Data:
62/563,32326.09.2017US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE VIA REDIRECTED T CELL IMMUNOTHERAPIES
(FR) COMPOSITIONS ET PROCÉDÉS POUR TRAITER UNE MALADIE CARDIAQUE PAR DES IMMUNOTHÉRAPIES À LYMPHOCYTES T REDIRIGÉS
Abstract:
(EN) The present invention includes compositions and methods for treating heart disease and/or heart failure. In one embodiment, the treatment includes administering to the subject a cell genetically modified to express a chimeric antigen receptor (CAR), comprising an antigen binding domain specific for fibroblast activation protein (FAP). In another embodiment, the treatment includes administering a cell genetically modified to express a T cell receptor (TCR) specific for an activated fibroblast.
(FR) La présente invention concerne des compositions et des procédés pour traiter une maladie cardiaque et/ou une insuffisance cardiaque. Dans un mode de réalisation, le traitement comprend l'administration au sujet d'une cellule génétiquement modifiée pour exprimer un récepteur d'antigène chimérique (CAR), comprenant un domaine liant l'antigène spécifique de la protéine d'activation des fibroblastes (FAP). Dans un autre mode de réalisation, le traitement comprend l'administration d'une cellule génétiquement modifiée pour exprimer un récepteur de lymphocytes T (TCR) spécifique d'un fibroblaste activé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)