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1. (WO2019067405) KETOGENIC DIET COMPATIBLE FENFLURAMINE FORMULATION
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Pub. No.: WO/2019/067405 International Application No.: PCT/US2018/052567
Publication Date: 04.04.2019 International Filing Date: 25.09.2018
IPC:
A61K 31/137 (2006.01) ,A61K 9/00 (2006.01) ,A61K 9/08 (2006.01) ,A61P 25/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
137
Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
08
Antiepileptics; Anticonvulsants
Applicants:
ABU-IZZA, Khawla [US/US]; US
HICKMAN, David [GB/GB]; GB
MORRISON, Glenn [CA/US]; US
BOYD, Brooks M. [US/US]; US
ZOGENIX INTERNATIONAL LIMITED [GB/GB]; Siena Court Broadway Maidenhead Berkshire SL6 1NJ, GB
Inventors:
ABU-IZZA, Khawla; US
HICKMAN, David; GB
MORRISON, Glenn; US
BOYD, Brooks M.; US
Agent:
BOZICEVIC, Karl; US
Priority Data:
16/140,12024.09.2018US
62/563,25526.09.2017US
62/564,22527.09.2017US
62/579,45031.10.2017US
62/582,17306.11.2017US
62/593,02930.11.2017US
62/627,32907.02.2018US
62/669,83310.05.2018US
62/696,80111.07.2018US
Title (EN) KETOGENIC DIET COMPATIBLE FENFLURAMINE FORMULATION
(FR) FORMULATION DE FENFLURAMINE COMPATIBLE AVEC UN RÉGIME CÉTOGÈNE
Abstract:
(EN) A method of treating symptoms of a subtype of epilepsy, e.g., Dravet syndrome, in a patient diagnosed with a subtype of epilepsy, by administering to the patient an effective dose of a fenfluramine formulation in combination with a ketogenic diet over a period of time sufficient to reduce or completely eliminate seizures in the patient. Also provided are compositions and kits finding use in practicing embodiments of the methods.
(FR) L'invention concerne une méthode de traitement de symptômes d'un sous-type d'épilepsie, par exemple, le syndrome de Dravet, chez un patient chez qui on a diagnostiqué un sous-type d'épilepsie, par l'administration au patient d'une dose efficace d'une formulation de fenfluramine en association avec un régime cétogène pendant une période de temps suffisante pour réduire ou éliminer complètement les crises d'épilepsie chez le patient. L'invention concerne également des compositions et des kits pouvant être utilisés dans la pratique des modes de réalisation des méthodes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)