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1. (WO2019067396) ZAP-70 KINASE INHIBITOR COMPOSITIONS, METHODS AND USES THEREOF
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Pub. No.: WO/2019/067396 International Application No.: PCT/US2018/052557
Publication Date: 04.04.2019 International Filing Date: 25.09.2018
IPC:
C07D 487/14 (2006.01) ,C07D 498/22 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/00 (2006.01) ,A61K 31/553 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
22
in which the condensed system contains four or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
553
having at least one nitrogen and at least one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
Applicants:
SNAP BIO, INC. [US/US]; 4757 Nexus Center Drive San Diego, California 92121, US
Inventors:
BURK, Mark J.; US
CHEN, Brandon; US
LI, Jingyi; US
BACHAN, Shawn; US
Agent:
BUSSE, Paul, W.; US
BERGER, Scott, A.; US
BINDER, Mark, W.; US
BJORKMAN, Dale, A.; US
DAHL, Philip, Y.; US
D'SOUZA, Tanya, S.; US
HAKAMAKI, Michaele, A.; US
KAGAN, David, B.; US
PARINS, Paul, J.; US
SARAGENO, Lori, P.; US
SCHULTE, Daniel, C.; US
WEAVER, Paul, L.; US
WARNER, Elizabeth, A.; US
Priority Data:
62/563,18626.09.2017US
Title (EN) ZAP-70 KINASE INHIBITOR COMPOSITIONS, METHODS AND USES THEREOF
(FR) COMPOSITIONS D'INHIBITEUR DE KINASE ZAP-70, PROCÉDÉS ET UTILISATIONS DE CELLES-CI
Abstract:
(EN) Disclosed are compounds of formulas (I) and (V) and compositions thereof useful as inhibitors of ZAP-70 kinase. Also provided are methods of synthesis and methods of use of ZAP-70 inhibitors in treating individuals suffering from organ transplant rejection, autoimmune diseases and cancer.
(FR) La présente invention concerne des composés représentés par les formules (I) et (V) et des compositions associées utilisables en tant qu'inhibiteurs de la kinase ZAP-70. L'invention concerne également des procédés de synthèse et des procédés d'utilisation d'inhibiteurs de ZAP-70 dans le traitement d'individus souffrant d'un rejet de greffe d'organe, de maladies auto-immunes et d'un cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)