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1. (WO2019067388) EXTRACTION OF SHORT NUCLEIC ACIDS BY NANOFIBERS
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Pub. No.: WO/2019/067388 International Application No.: PCT/US2018/052540
Publication Date: 04.04.2019 International Filing Date: 25.09.2018
IPC:
C01G 23/047 (2006.01) ,C08K 3/11 (2018.01) ,C12N 15/10 (2006.01) ,C12Q 1/68 (2018.01)
C CHEMISTRY; METALLURGY
01
INORGANIC CHEMISTRY
G
COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F94
23
Compounds of titanium
04
Oxides; Hydroxides
047
Titanium dioxide
[IPC code unknown for C08K 3/11]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 5th Floor Oakland, CA 94607, US
Inventors:
JIMENEZ, Luis Armando; US
ZHONG, Wenwan; US
Agent:
JACOBS, Ron; US
MCFARLANE, Thomas, J.; US
LODENKAMPER, Robert; US
PARRIS, James; US
Priority Data:
62/566,35730.09.2017US
Title (EN) EXTRACTION OF SHORT NUCLEIC ACIDS BY NANOFIBERS
(FR) EXTRACTION D'ACIDES NUCLÉIQUES COURTS PAR DES NANOFIBRES
Abstract:
(EN) Titanium oxide nanofibers were fabricated and employed to extract small nucleic acids including RNA and DNA, and series-solution recipes were created to recover small nucleic acids from different biological samples with high recovery and size selectivity (size < 500 nt). This extraction technique is useful for purifying and enriching small RNA from clinical specimens like plasma and serum, and from biological samples, like tissue or cell lysates, which is needed in discovery new small RNA-based biomarkers, in development of new therapies, and in other areas that focus on small RNA functions.
(FR) Des nanofibres d'oxyde de titane ont été fabriquées et utilisées pour extraire de petits acides nucléiques comprenant de l'ARN et de l'ADN, et des recettes en solution en série ont été créées pour récupérer de petits acides nucléiques dans différents échantillons biologiques avec une récupération et une sélectivité de taille élevées (taille < 500 nt). Cette technique d'extraction est utile pour purifier et enrichir un petit ARN provenant d'échantillons cliniques comme le plasma et le sérum, et provenant d'échantillons biologiques, comme des lysats de tissu ou de cellule, ce qui est nécessaire dans la découverte de nouveaux biomarqueurs à base d'ARN, dans le développement de nouvelles thérapies, et dans d'autres secteurs qui se concentrent sur les fonctions de petits ARN.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)