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1. (WO2019067243) T CELL RECEPTORS RECOGNIZING MUTATED P53
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/067243 International Application No.: PCT/US2018/051285
Publication Date: 04.04.2019 International Filing Date: 17.09.2018
IPC:
C07K 14/725 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
725
T-cell receptors
Applicants:
DENIGER, Drew C. [US/US]; US (US)
ROSENBERG, Steven A. [US/US]; US (US)
PASETTO, Anna [IT/US]; US (US)
YOSEPH, Rami [IL/US]; US (US)
LO, Winifred M. [US/US]; US (US)
LU, Yong-Chen [CN/US]; US (US)
PARKHURST, Maria R. [US/US]; US (US)
ROBBINS, Paul F. [US/US]; US (US)
MALEKZADEH, Parisa [US/US]; US (US)
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer, National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, Maryland 20892-7660, US (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
Inventors:
DENIGER, Drew C.; US
ROSENBERG, Steven A.; US
PASETTO, Anna; US
YOSEPH, Rami; US
LO, Winifred M.; US
LU, Yong-Chen; US
PARKHURST, Maria R.; US
ROBBINS, Paul F.; US
MALEKZADEH, Parisa; US
Agent:
LAWLEY, Stephanie M.; US
Priority Data:
62/565,38329.09.2017US
Title (EN) T CELL RECEPTORS RECOGNIZING MUTATED P53
(FR) RÉCEPTEURS DE LYMPHOCYTES T RECONNAISSANT P53 MUTÉE
Abstract:
(EN) Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
(FR) L'invention concerne un récepteur de lymphocytes T (TCR) isolé ou purifié ayant une spécificité antigénique pour p53 humain mutée. La présente invention concerne également des polypeptides et des protéines associés, ainsi que des acides nucléiques, des vecteurs d'expression recombinants, des cellules hôtes, des populations de cellules et des compositions pharmaceutiques associés. La présente invention concerne en outre des procédés pour détecter la présence d'un cancer chez un mammifère, et des méthodes de traitement ou de prévention d'un cancer chez un mammifère.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)