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1. (WO2019067180) NIR TO SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION
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Pub. No.: WO/2019/067180 International Application No.: PCT/US2018/049921
Publication Date: 04.04.2019 International Filing Date: 07.09.2018
IPC:
C07D 333/74 (2006.01) ,C07D 401/08 (2006.01) ,C07D 403/08 (2006.01) ,C07D 403/14 (2006.01) ,C07D 409/08 (2006.01) ,C07D 209/90 (2006.01) ,C07D 209/92 (2006.01) ,A61P 35/00 (2006.01) ,A61K 31/403 (2006.01) ,A61K 31/473 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
50
condensed with carbocyclic rings or ring systems
74
Naphthothiophenes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
08
linked by a carbon chain containing alicyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
08
linked by a carbon chain containing alicyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
08
linked by a carbon chain containing alicyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56
Ring systems containing three or more rings
80
[b, c]- or [b, d]-condensed
90
Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56
Ring systems containing three or more rings
80
[b, c]- or [b, d]-condensed
90
Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
92
Naphthostyrils
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
473
ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
Applicants:
PERKINELMER HEALTH SCIENCES, INC. [US/US]; 940 Winter Street Waltham, MA 02451, US
Inventors:
NARAYANAN, Nara; US
GROVES, Kevin; US
HO, Guojie; US
Agent:
GOULD, Weston, R.; US
MCEVOY, Douglas, J.; US
ANDERSON, Thomas, E.; US
MACKENZIE, Kevin, S.; US
GOULD, Weston, R.; US
Priority Data:
62/565,26329.09.2017US
Title (EN) NIR TO SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION
(FR) COMPOSÉS FLUORESCENTS NIR À SWIR DESTINÉS À L'IMAGERIE ET À LA DÉTECTION
Abstract:
(EN) This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 run), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIRin vivoimaging of regions of interest (I) within a mammal.
(FR) La présente invention concerne une famille de composés qui absorbent et émettent une fluorescence dans la région infrarouge à courtes longueurs d'ondes (SWIR, éventuellement 1000 nm à 1300 nm), y compris des composés hydrophiles qui présentent des profils spectraux d'absorption et d'émission dans des solutions aqueuses sensiblement similaires à celles observées dans des solvants organiques tels que le méthanol ou le DMSO. Les composés peuvent être chimiquement liés à des biomolécules notamment des protéines, des acides nucléiques et des petites molécules thérapeutiques. Les composés sont destinés à être utilisés dans l'imagerie pour une large gamme d'applications médicales, biologiques et de diagnostic, notamment l'imagerie SWIRin vivo de régions d'intérêt (I) chez un mammifère.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)