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1. (WO2019067145) USE OF CYCLODEXTRINS IN DISEASES AND DISORDERS INVOLVING PHOSPHOLIPID DYSREGULATION
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Pub. No.: WO/2019/067145 International Application No.: PCT/US2018/048414
Publication Date: 04.04.2019 International Filing Date: 28.08.2018
IPC:
A61K 47/40 ,A61K 9/00 (2006.01) ,A61K 9/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
40
Cyclodextrins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
Applicants:
ASDERA LLC [US/US]; 220 E. 70th Street, #5C New York, NY 10021, US
Inventors:
WITTKOWSKI, Knut, M.; US
Agent:
ZURAWSKI, John, A.; US
BROWN, Ronald; US
BAI, Mei; US
BLAZESKI, George; US
BOWLES, Anita, M.; US
Priority Data:
62/551,19304.12.2017US
62/565,05328.09.2017US
62/573,65817.10.2017US
62/586,82615.11.2017US
62/643,69415.03.2018US
62/679,91203.06.2018US
Title (EN) USE OF CYCLODEXTRINS IN DISEASES AND DISORDERS INVOLVING PHOSPHOLIPID DYSREGULATION
(FR) UTILISATION DE CYCLODEXTRINES DANS DES MALADIES ET DES TROUBLES IMPLIQUANT UN DÉRÈGLEMENT DES PHOSPHOLIPIDES
Abstract:
(EN) The present disclosure provides certain compositions and methods that may be useful in the treatment and/or prevention of a malignant, neurodegenerative, cardiovascular, metabolic, inflammatory, autoimmune, or viral disease or disorder, such as carcinomas, Alzheimer's and Parkinson's disease, multiple sclerosis, Paget's disease, or other aspects of aging, such as atherosclerosis or type-2 diabetes. In some such embodiments, compositions are provided that contain at least one cyclodextrin active agent, such as alpha-cyclodextrin, or an analogue or derivative thereof. In some embodiment the composition is a clathrate of HP-aCD and sodium caprate or caprylate.
(FR) La présente invention concerne certains procédés et compositions qui peuvent être utiles dans le traitement et/ou la prévention d'une maladie ou d'un trouble malin, neurodégénératif, cardiovasculaire, métabolique, inflammatoire, auto-immun ou viral, tel que des carcinomes, la maladie d'Alzheimer et la maladie de Parkinson, la sclérose en plaques, la maladie de Paget, ou d'autres aspects du vieillissement, tels que l'athérosclérose ou le diabète de type 2. Dans certains de ces modes de réalisation, l'invention concerne des compositions qui contiennent au moins un agent actif du type cyclodextrine, tel que l'alpha-cyclodextrine, ou un analogue ou un dérivé de celle-ci. Dans un mode de réalisation, la composition est un clathrate de HP-aCD et du caprate ou du caprylate de sodium.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)