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1. (WO2019066644) METHODS FOR PROVIDING HIGHLY PURE PALMITOYLETHANOLAMIDE (PEA), PURE PEA PREPARATIONS, AND USES THEREOF
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Pub. No.: WO/2019/066644 International Application No.: PCT/NL2017/050647
Publication Date: 04.04.2019 International Filing Date: 28.09.2017
IPC:
C07C 231/24 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
231
Preparation of carboxylic acid amides
22
Separation; Purification; Stabilisation; Use of additives
24
Separation; Purification
Applicants:
INNEXUS NUTRACEUTICALS B.V. [NL/NL]; Groesbeekseweg 2 6524 DA Nijmegen, NL
Inventors:
KELLER, Erik; NL
DABBOUS, Samuel Johannes; NL
Agent:
JANSEN, C.M.; V.O. Carnegieplein 5 2517 KJ Den Haag, NL
Priority Data:
Title (EN) METHODS FOR PROVIDING HIGHLY PURE PALMITOYLETHANOLAMIDE (PEA), PURE PEA PREPARATIONS, AND USES THEREOF
(FR) PROCÉDÉS PERMETTANT DE FOURNIR UNE PALMITOYLÉTHANOLAMIDE (PEA) TRÈS PURE, PRÉPARATIONS DE PEA PURES ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) The invention relates to the field of medicinal chemistry, more in particular to methods for providing highly pure, pharmaceutical grade synthetic Palmitoylethanolamine (PEA), to pure PEA preparations obtainable thereby, and the uses thereof. Provided is a method for providing pure PEA, comprising the steps of (i) heating a suspension of crude PEA in a solvent mixture in the presence of a base catalyst having a pKA of at least 13 to reflux, thereby allowing the formation of crystalline PEA; and (ii) isolating said crystalline PEA.
(FR) L'invention se rapporte au domaine de la chimie médicale, et concerne plus particulièrement des procédés permettant de fournir une palmitoyléthanolamine (PEA) synthétique de qualité pharmaceutique très pure, des préparations de PEA pures pouvant être obtenues par ledit procédé, ainsi que leurs utilisations. L'invention concerne un procédé permettant de fournir une PEA pure, comprenant les étapes consistant à (i) chauffer une suspension de PEA brute dans un mélange de solvants en présence d'un catalyseur de base ayant un pKA d'au moins 13 jusqu'au reflux, ce qui permet de former une PEA cristalline ; et (ii) isoler ladite PEA cristalline.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)