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1. (WO2019066621) COMPOSITION FOR DETECTING RAS/BRAF MUTATIONS, AND KIT COMPRISING SAME
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Pub. No.: WO/2019/066621 International Application No.: PCT/KR2018/011645
Publication Date: 04.04.2019 International Filing Date: 01.10.2018
IPC:
C12Q 1/6883 (2018.01)
[IPC code unknown for C12Q 1/6883]
Applicants:
주식회사 젠큐릭스 GENCURIX INC. [KR/KR]; 서울시 구로구 디지털로 242, 402호, 403호, 404호, 908호, 910호, 911호 (구로동, 한화비즈메트로1차) (Hanhwa Bizmetro 1-cha, Guro-dong) #402, #403, #404, #908, #910, #911 242, Digital-ro Guro-gu Seoul 08394, KR
재단법인 록원바이오융합연구재단 LOGONE BIO CONVERGENCE RESEARCH FOUNDATION [KR/KR]; 서울 관악구 관악로 1, 20동 4층 414, 415호(봉천동) (Bongcheon-dong) #414, #415, 4th Fl., 20 dong, 1, Gwanak-ro Gwanak-gu Seoul 08826, KR
Inventors:
신영기 SHIN, Young Kee; KR
김성수 KIM, Sung Su; KR
조상래 CHO, Sang Rae; KR
문영호 MOON, Young Ho; KR
김지은 KIM, Jee Eun; KR
강병일 KANG, Byeong-il; KR
류다연 RYU, Dayeon; KR
Agent:
이희숙 LEE, Hee Sook; 서울시 강남구 테헤란로 33길 11, 9층 (역삼동, JS 빌딩) (JS building, Yeoksam-dong) 9th Fl, 11, Teheran-ro 33 gil Gangnam-gu Seoul 06141, KR
Priority Data:
10-2017-012833529.09.2017KR
Title (EN) COMPOSITION FOR DETECTING RAS/BRAF MUTATIONS, AND KIT COMPRISING SAME
(FR) COMPOSITION POUR DÉTECTER DES MUTATIONS RAS/BRAF, ET KIT LA COMPRENANT
(KO) RAS/BRAF 돌연변이 검출용 조성물 및 이를 포함하는 키트
Abstract:
(EN) The present invention relates to a composition for detecting RAS/BRAF mutations and a kit comprising same and, more specifically, to a primer and probe set composition for detecting RAS/BRAF mutations and a kit for detecting RAS/BRAF mutations comprising the composition. A method according to the present invention enables prediction of the metastasis or recurrence of cancer, as well as prediction and diagnosis of responsiveness to a therapeutic agent according to prognosis of a cancer patient, and thus can be usefully employed for the purpose of providing clues to the future course of treatment, including determination of the need for administering an anticancer therapeutic agent, and in monitoring for metastasis or recurrence of cancer.
(FR) La présente invention concerne une composition pour détecter des mutations RAS/BRAF et un kit la comprenant et, plus spécifiquement, une composition de type ensemble d'amorce et de sonde pour détecter les mutations RAS/BRAF et un kit pour détecter les mutations RAS/BRAF comprenant ladite composition. La méthode selon la présente invention permet de prédire la métastase ou la récidive du cancer, et de prédire et de diagnostiquer la réactivité à un agent thérapeutique en fonction du pronostic d'un patient atteint de cancer, et peut ainsi être avantageusement utilisée pour fournir des indices pour le futur traitement, comprenant la détermination de l'administration nécessaire d'un agent thérapeutique anticancéreux, et pour surveiller la métastase ou la récidive du cancer.
(KO) 본 발명은 RAS/BRAF 돌연변이 검출용 조성물 및 이를 포함하는 키트에 관한 것으로, 보다 상세하게는 RAS/BRAF 돌연변이 검출용 프라이머 및 프로브 세트 조성 물과 상기 조성물을 포함하는 RAS/BRAF돌연변이 검출용 키트에 관한 것이다. 본 발명의 방법은 암 환자 예후의 치료제에 대한 반응성 예측, 진단뿐만 아 니라 암의 전이 또는 재발에 대한 예측이 가능하므로 항암치료제의 투여 필요성 판 단을 비롯하여 향후 치료의 방향에 대한 단서를 제시하는 목적 및 암의 전이 또는 재발에 대한모니터링 하는 데에 유용하게 이용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)