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1. (WO2019066620) ANTI-C-MET ANTIBODY AND USES THEREOF
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Pub. No.: WO/2019/066620 International Application No.: PCT/KR2018/011644
Publication Date: 04.04.2019 International Filing Date: 01.10.2018
IPC:
C07K 16/28 (2006.01) ,C12N 5/09 (2010.01) ,G01N 33/574 (2006.01) ,G01N 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
09
Tumour cells
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35
Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
Applicants:
서울대학교산학협력단 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR/KR]; 서울특별시 관악구 관악로1 (신림동) (Sillim-dong)1, Gwanak-ro, Gwanak-gu, Seoul 08826, KR
주식회사 지노바이오 GENOBIO CORP. [KR/KR]; 서울특별시 구로구 디지털로 242, 714호 (구로동, 한화비즈메트로1차) (Hanhwa Bizmetro 1-cha, Guro-dong) #714, 242 Digital-ro Guro-gu Seoul 08394, KR
에이비온 주식회사 ABION INC. [KR/KR]; 서울시 구로구 디지털로 242, 915호 (구로동, 한화비즈 메트로1차) (Hanhwa Bizmetro 1-cha, Guro-dong) #915, 242, Digital-ro, Guro-gu Seoul 08394, KR
Inventors:
신영기 SHIN, Young Kee; KR
이지혜 LEE, Ji Hye; KR
김영덕 KIM, Young Deug; KR
이재구 LEE, Jae Ku; KR
이훈석 LEE, Hun Seok; KR
Agent:
이희숙 LEE, Hee Sook; 서울특별시 강남구 테헤란로 33길 11, 9층 (역삼동, JS빌딩) (JS Building, Yeoksam-dong) 9th Fl. 11, Teheran-ro 33 gil Gangnam-gu Seoul 06141, KR
Priority Data:
10-2017-012828729.09.2017KR
Title (EN) ANTI-C-MET ANTIBODY AND USES THEREOF
(FR) ANTICORPS ANTI-C-MET ET SES UTILISATIONS
(KO) 항 C-MET 항체 및 이의 용도
Abstract:
(EN) The present invention relates to an anti-c-Met antibody and uses thereof and more specifically to: an antibody, or a fragment thereof, which specifically binds to a human c-Met protein; a method for producing same; a c-Met-specific detection method using same; a circulating tumor cell (CTC) detection method using same; and a kit for circulating tumor cell detection comprising same as an active ingredient. The methods according to the present invention can be usefully employed in detecting c-Met antibodies and detecting circulating tumor cells in blood by means of the antibodies.
(FR) La présente invention concerne un anticorps anti-c-Met et ses utilisations et plus précisément : un anticorps, ou un fragment de celui-ci, qui se lie spécifiquement à une protéine c-Met humaine; un procédé de production de celui-ci; un procédé de détection spécifique de c-Met l'utilisant; un procédé de détection de cellules tumorales circulantes (CTC) l'utilisant; et un kit de détection de cellules tumorales circulantes le comprenant en tant que principe actif. Les procédés selon la présente invention peuvent être utilisés utilement dans la détection d'anticorps c-Met et la détection de cellules tumorales circulantes dans le sang au moyen des anticorps.
(KO) 본 발명은 항 c-Met 항체 및 이의 용도에 관한 것으로, 보다 상세하게는 인간 유래 c-Met 단백질에 특이적으로 결합하는 항체 또는 그 단편, 이의 생산방법, 이를 이용한 c-Met 특이적 검출 방법, 이를 이용한 순환암세포 (Circulating Tumor Cell, CTC) 검출 방법 및 이를 유효성분으로 포함하는 순환암세포 검출용 키트에 관한 것이다. 본 발명의 방법은 c-Met 항체를 검출하고, 항체를 이용하여 혈액 내의 순환암세포를 검출하는 데에 유용하게 이용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)