Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019066578) PROCESS FOR PREPARING INTERMEDIATE COMPOUND FOR PHARMACEUTICAL SYNTHESIS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/066578 International Application No.: PCT/KR2018/011565
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
C07C 269/00 (2006.01) ,C07C 271/22 (2006.01) ,C07D 263/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
269
Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
08
having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10
with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
22
to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02
not condensed with other rings
08
having one double bond between ring members or between a ring member and a non-ring member
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18
Oxygen atoms
Applicants:
주식회사 엘지화학 LG CHEM, LTD. [KR/KR]; 서울시 영등포구 여의대로 128 128, Yeoui-daero, Yeongdeungpo-gu, Seoul 07336, KR
Inventors:
이석주 LEE, Seok Ju; KR
김봉찬 KIM, Bongchan; KR
박애리 PARK, Ae Ri; KR
류인애 RYU, In Ae; KR
박종원 PARK, Jongwon; KR
Agent:
유미특허법인 YOU ME PATENT AND LAW FIRM; 서울시 강남구 테헤란로 115 115 Teheran-ro Gangnam-gu Seoul 06134, KR
Priority Data:
10-2017-012611928.09.2017KR
10-2018-011583828.09.2018KR
Title (EN) PROCESS FOR PREPARING INTERMEDIATE COMPOUND FOR PHARMACEUTICAL SYNTHESIS
(FR) PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ INTERMÉDIAIRE POUR UNE SYNTHÈSE PHARMACEUTIQUE
(KO) 의약품 합성용 중간체 화합물의 제조 방법
Abstract:
(EN) The present invention relates to a process for preparing a compound of formula 2 that is an intermediate used to synthesize a dipeptidyl peptidase IV enzyme-inhibiting therapeutic agent for treating diabetes mellitus, which (1) can be produced in high purity through an oxazolidinone cyclization reaction and a decyclization reaction of converting the same into amide, (2) can lead to an increase in yield and productivity through stabilization of a production process, and (3) can achieve an improved effect, such as reduction of raw material costs, by using an inexpensive material as a starting material.
(FR) La présente invention concerne un procédé de préparation d'un composé de formule 2 qui est un intermédiaire utilisé pour synthétiser un agent thérapeutique inhibant l'enzyme dipeptidyle peptidase IV pour le traitement du diabète sucré, qui (1) peut être produit en pureté élevée par l'intermédiaire d'une réaction de cyclisation d'oxazolidinone et d'une réaction de décyclisation pour la conversion de celui-ci en amide, (2) peut conduire à une augmentation du rendement et de la productivité par la stabilisation d'un procédé de production, et (3) qui peut obtenir un effet amélioré, tel qu'une réduction des coûts de matière première, en utilisant un matériau peu coûteux en tant que matériau de départ.
(KO) 본 발명은, 디펩티딜 펩티데이즈 IV 효소 억제 당뇨병 치료제를 합성하는데 사용되는 중간체인 화학식 2의 화합물을 1) 옥사졸리디논 고리화 반응 및 아마이드로 전환하는 탈고리화 반응을 통해 높은 순도로 생산할 수 있고, 2) 제조공정의 안정화를 통해 수율 증가 및 생산성 증대가 가능하며, 그리고 3) 값싼 시료의 출발물질을 사용하여 원재료비 절감 등의 개선효과를 성취할 수 있는 제조방법에 관한 것이다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)