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1. (WO2019066571) METHOD FOR PRODUCING MYELOID-DERIVED SUPPRESSOR CELLS, MYELOID-DERIVED SUPPRESSOR CELLS PRODUCED THEREBY, AND USES THEREOF
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Pub. No.: WO/2019/066571 International Application No.: PCT/KR2018/011558
Publication Date: 04.04.2019 International Filing Date: 28.09.2018
IPC:
C12N 5/071 (2010.01) ,C12N 5/0784 (2010.01) ,A61K 35/15 ,A61K 39/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0784
Dendritic cells; Progenitors thereof
[IPC code unknown for A61K 35/15]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
연세대학교 산학협력단 INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY [KR/KR]; 서울시 서대문구 연세로 50 50, Yonsei-ro Seodaemun-gu Seoul 03722, KR
Inventors:
신성재 SHIN, Sung Jae; KR
김우식 KIM, Woo Sik; KR
김홍민 KIM, Hong Min; KR
권기웅 KWON, Kee Woong; KR
윤주헌 YOON, Joo Heon; KR
고원중 KOH, Won Jung; KR
Agent:
이재영 LEE, Jae Young; KR
Priority Data:
10-2017-012596828.09.2017KR
10-2017-012599028.09.2017KR
10-2017-012637928.09.2017KR
Title (EN) METHOD FOR PRODUCING MYELOID-DERIVED SUPPRESSOR CELLS, MYELOID-DERIVED SUPPRESSOR CELLS PRODUCED THEREBY, AND USES THEREOF
(FR) PROCÉDÉ DE PRODUCTION DE CELLULES SUPPRESSIVES D'ORIGINE MYÉLOÏDE, CELLULES SUPPRESSIVES D'ORIGINE MYÉLOÏDE AINSI PRODUITES ET LEURS UTILISATIONS
(KO) 골수유래 면역반응 억제세포의 제조방법, 이에 의해 제조된 골수유래 면역반응 억제세포 및 그 용도
Abstract:
(EN) The present invention relates to a method for inducing differentiation of bone marrow cells into myeloid-derived suppressor cells (MDSCs) by treating the bone marrow cells with a toll-like receptor agonist (TLR agonist) or a type I interferon or for inducing dendritic cells from the MDSCs.
(FR) La présente invention concerne un procédé pour l'induction de la différenciation de cellules de moelle osseuse en cellules suppressives d'origine myéloïde (MDSC) consistant à traiter les cellules de moelle osseuse à l'aide d'un agoniste des récepteurs de type Toll (agoniste des TLR) ou d'un interféron de type I ou pour l'induction de cellules dendritiques à partir des MDSC.
(KO) 골수 세포에 톨 유사 수용체 작용제(toll-like receptor agonist, TLR agonist) 또는 Ⅰ형 인터페론(type Ⅰ interferon)을 처리하여 골수유래 면역반응 억제세포(myeloid-derived suppressor cells, MDSCs)로 분화를 유도하거나, 이로부터 수지상 세포를 유도하는 방법에 관한 것이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)