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1. (WO2019066469) USE OF FEBUXOSTAT OR TOPIROXOSTAT AS AGENT FOR PREVENTION AND TREATMENT OF CANCER METASTASIS
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Pub. No.: WO/2019/066469 International Application No.: PCT/KR2018/011386
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
A61K 31/426 (2006.01) ,A61K 31/4439 (2006.01) ,A23L 33/10 (2016.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
[IPC code unknown for A23L 33/10]
Applicants:
경북대학교 산학협력단 KYUNGPOOK NATIONAL UNIVERISTY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 대구광역시 북구 대학로 80 (산격동, 경북대학교) (Kyungpook National University, Sangyeok-dong) 80, Daehak-ro, Buk-gu Daegu 41566, KR
경북대학교병원 KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL [KR/KR]; 대구시 중구 동덕로130(삼덕동2가) (Samdeok-dong 2-ga)130, Dongdeok-ro, Jung-gu Daegu, Daegu 41944, KR
Inventors:
김용림 KIM, Yong Lim; KR
최순연 CHOI, Soon Youn; KR
오세현 OH, Se Hyun; KR
Agent:
이희숙 LEE, Hee Sook; 서울특별시 강남구 테헤란로 33길 11, 9층 (역삼동, JS빌딩) (JS Building, Yeoksam-dong) 9th Fl. 11, Teheran-ro 33 gil Gangnam-gu, Seoul 06141, KR
Priority Data:
10-2017-012544327.09.2017KR
10-2018-000566716.01.2018KR
Title (EN) USE OF FEBUXOSTAT OR TOPIROXOSTAT AS AGENT FOR PREVENTION AND TREATMENT OF CANCER METASTASIS
(FR) UTILISATION DE FÉBUXOSTAT OU DE TOPIROXOSTAT EN TANT QU'AGENT POUR LA PRÉVENTION ET LE TRAITEMENT DE MÉTASTASES CANCÉREUSES
(KO) 페북소스타트 또는 토피록소스타트의 암 전이의 예방 및 치료제로서의 용도
Abstract:
(EN) The present invention relates to a novel use of febuxostat or topiroxostat and, more specifically, to a pharmaceutical composition for suppression of cancer metastasis and prevention and treatment of cancer, the pharmaceutical composition containing, as an active ingredient, at least one selected from the group consisting of febuxostat, topiroxostat, and pharmaceutically acceptable salts thereof. The febuxostat or topiroxostat has a remarkable effect of specifically suppressing cancer metastasis, thereby providing a novel means for prevention and treatment of cancer.
(FR) La présente invention concerne une nouvelle utilisation du fébuxostat ou de topiroxostat et, plus spécifiquement, une composition pharmaceutique pour la suppression de métastases cancéreuses et la prévention et le traitement du cancer, la composition pharmaceutique contenant, en tant que principe actif, au moins un élément choisi dans le groupe constitué par le febuxostat, le topiroxostat, et des sels pharmaceutiquement acceptables associés. Le fébuxostat ou le topiroxostat a un effet remarquable de suppression spécifique de métastases cancéreuses, constituant ainsi un nouveau moyen de prévention et de traitement du cancer.
(KO) 본 발명은 페북소스타트 (febuxostat) 또는 토피록소스타트 (topiroxostat)의 신규한 용도에 관한 것으로, 보다 상세하게는 페북소스타트, 토피록소스타트 및 이들의 약학적으로 허용 가능한 염으로 이루어진 군에서 선택되는 어느 하나 이상의 것을 유효성분으로 포함하는 암 전이 억제, 암의 예방 및 치료용 약학적 조성물에 대한 것이다. 페북소스타트 (febuxostat), 토피록소스타트 (topiroxostat)는 암의 전이를 특이적으로 억제하는 효과가 현저하여, 암 예방 및 치료를 위한 새로운 수단을 제공한다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)