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1. (WO2019066467) NOVEL METHOD FOR PREPARING (2R)-2-(2-METHOXYPHENYL)-2-(OXANE-4-YLOXY)ETHANE-1-OL COMPOUND, AND INTERMEDIATE USED THEREIN
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Pub. No.: WO/2019/066467 International Application No.: PCT/KR2018/011383
Publication Date: 04.04.2019 International Filing Date: 27.09.2018
IPC:
C07D 309/10 (2006.01) ,A61K 31/351 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
02
having no double bonds between ring members or between ring members and non-ring members
08
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
10
Oxygen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
351
not condensed with another ring
Applicants:
한미약품 주식회사 HANMI PHARM. CO., LTD. [KR/KR]; 경기도 화성시 팔탄면 무하로 214 214, Muha-ro, Paltan-myeon, Hwaseong-si, Gyeonggi-do 18536, KR
Inventors:
장욱 JANG, Wook; KR
백종욱 BAEK, Jong Ouk; KR
김희철 KIM, Hee Cheol; KR
하태희 HA, Tae Hee; KR
Agent:
김성호 KIM, Sung Ho; KR
박형달 PARK, Hyung-Dal; KR
Priority Data:
10-2017-012592828.09.2017KR
Title (EN) NOVEL METHOD FOR PREPARING (2R)-2-(2-METHOXYPHENYL)-2-(OXANE-4-YLOXY)ETHANE-1-OL COMPOUND, AND INTERMEDIATE USED THEREIN
(FR) NOUVEAU PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ DE (2R)-2-(2-MÉTHOXYPHÉNYL)-2-(OXANE-4-YLOXY)ÉTHANE-1-OL, ET INTERMÉDIAIRE UTILISÉ À CET EFFET
(KO) (2R)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체
Abstract:
(EN) Provided in the present invention are: a novel method for preparing a compound of chemical formula 1, comprising a step of obtaining a compound of chemical formula 1 by performing a reduction reaction on a compound of chemical formula 2; and an intermediate used therein. According to the preparation method of the present invention, the compound of chemical formula 1, which is useful for the production of an acetyl-CoA carboxylase (ACC) inhibitor, can be mass-produced more simply and efficiently than that of a conventional method.
(FR) La présente invention concerne : un nouveau procédé de préparation d'un composé de formule chimique 1, comprenant une étape d'obtention d'un composé de formule chimique 1 par réalisation d'une réaction de réduction sur un composé de formule chimique 2; et un intermédiaire utilisé dans ledit procédé. Selon le procédé de préparation de la présente invention, le composé de formule chimique 1, qui est utile pour la production d'un inhibiteur d'acétyl-CoA carboxylase (ACC), peut être produit en masse de manière plus simple et efficace par rapport à celui d'un procédé classique.
(KO) 본 발명은 화학식 2의 화합물에 대하여 환원반응을 수행하여 화학식 1의 화합물을 얻는 단계를 포함하는 화학식 1의 화합물의 신규 제조방법 및 이에 사용되는 중간체를 제공한다. 본 발명의 제조방법에 따르면, 아세틸-코에이 카르복실라제(Acetyl-CoA carboxylase, ACC)의 억제제 제조에 유용한 화학식 1의 화합물을 종래 기술보다 간편하고, 효율적으로 대량생산할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)