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1. (WO2019066389) NC FUSION PROTEIN COMPRISING N-TERMINAL DOMAIN FRAGMENT AND C-TERMINAL DOMAIN FRAGMENT OF NUCLEOCAPSID PROTEIN OF MERS CORONAVIRUS, AND KIT FOR DIAGNOSING MERS CORONAVIRUS INFECTION BY USING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/066389 International Application No.: PCT/KR2018/011155
Publication Date: 04.04.2019 International Filing Date: 20.09.2018
IPC:
C07K 14/005 (2006.01) ,C07K 16/10 (2006.01) ,G01N 33/569 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
03
Herpetoviridae, e.g. pseudorabies virus
05
Epstein-Barr virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08
against material from viruses
10
from RNA viruses
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
한국생명공학연구원 KOREA RESEARCH INSTITUTE OF BIOSCEINCE AND BIOTECHNOLOGY [KR/KR]; 대전시 유성구 과학로 125 125 Gwahak-ro Yuseong-gu Daejeon 34141, KR
Inventors:
정대균 JEONG, Dae Gwin; KR
윤선우 YOON, Sun Woo; KR
김혜권 KIM, Hye Kwon; KR
송대섭 SONG, Daesub; KR
노지영 NOH, Jiyeong; KR
안민주 AHN, Min Ju; KR
Agent:
제일특허법인(유) FIRSTLAW P.C.; 서울시 서초구 마방로 60 60 Mabang-Ro Seocho-Ku Seoul 06775, KR
Priority Data:
10-2017-012439426.09.2017KR
Title (EN) NC FUSION PROTEIN COMPRISING N-TERMINAL DOMAIN FRAGMENT AND C-TERMINAL DOMAIN FRAGMENT OF NUCLEOCAPSID PROTEIN OF MERS CORONAVIRUS, AND KIT FOR DIAGNOSING MERS CORONAVIRUS INFECTION BY USING SAME
(FR) PROTÉINE DE FUSION NC COMPRENANT UN FRAGMENT DE DOMAINE N-TERMINAL ET UN FRAGMENT DE DOMAINE C-TERMINAL DE LA PROTÉINE DE NUCLÉOCAPSIDE DU CORONAVIRUS DU SRMO, ET KIT DE DIAGNOSTIC D'UNE INFECTION À CORONAVIRUS DU SRMO UTILISANT LADITE PROTÉINE DE FUSION NC
(KO) 메르스 코로나바이러스의 뉴클레오캡시드 단백질의 N-말단 도메인 단편 및 C-말단 도메인 단편을 포함한 NC 융합 단백질 및 이를 이용한 메르스 코로나바이러스 감염 진단용 키트
Abstract:
(EN) The present invention relates to: an NC fusion protein comprising N-terminal and C-terminal domain fragments of a nucleocapsid protein of MERS coronavirus; and a kit for diagnosing MERS coronavirus infection by using the same. An NC fusion protein of the present invention can be mass-produced, in E. coli, much more stably than a full-length nucleocapsid protein. In addition, according to the present invention, when the NC fusion protein represented by SEQ ID NO: 8 is used as an antigen, an antibody specific to MERS coronavirus can be effectively produced. Furthermore, since the NC fusion protein reacts with an antibody induced by MERS coronavirus, the NC fusion protein can be used in a kit for diagnosing MERS coronavirus.
(FR) La présente invention concerne : une protéine de fusion NC comprenant des fragments de domaine N-terminal et C-terminal d'une protéine de nucléocapside du coronavirus du SRMO ; et un kit de diagnostic d'une infection à coronavirus du SRMO utilisant ladite protéine de fusion NC. Une protéine de fusion NC selon la présente invention peut être produite en masse, dans E coli, de manière beaucoup plus stable qu'une protéine de nucléocapside pleine longueur. De plus, selon la présente invention, lorsque la protéine de fusion NC représentée par SEQ ID NO : 8 est utilisée en tant qu'antigène, un anticorps spécifique du coronavirus du SRMO peut être efficacement produit. En outre, étant donné que la protéine de fusion NC réagit avec un anticorps induit par le coronavirus du SRMO, la protéine de fusion NC peut être utilisée dans un kit de diagnostic du coronavirus du SRMO.
(KO) 본 발명은 메르스 코로나바이러스 뉴클레오캡시드 단백질의 N-말단 및 C- 말단 도메인 단편을 포함하는 NC 융합 단백질 및 이를 이용한 메르스 코로나바이러스 감염 진단용 키트에 관한 것이다. 본 발명의 NC 융합 단백질은 대장균에서 뉴클레오캡시드 전장 단백질보다 훨씬 더 안정하게 대량 생산이 가능하다. 또한, 본 발명에 따른 서열번호 8로 표시되는 NC 융합 단백질을 항원으로 하였을 때, 메르스 코로나바이러스에 특이적인 항체를 효과적으로 생산할 수 있다. 또한, 상기 NC 융합 단백질은 메르스 코로나바이러스에 의해 유도되는 항체에 반응을 하므로, 상기 NC 융합 단백질은 메르스 코로나바이러스 진단 키트에 활용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)