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1. (WO2019066359) COMBINED PHARMACEUTICAL FORMULATION COMPRISING DAPAGLIFLOZIN L-PROLINE AND METFORMIN
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Pub. No.: WO/2019/066359 International Application No.: PCT/KR2018/011004
Publication Date: 04.04.2019 International Filing Date: 18.09.2018
IPC:
A61K 9/50 (2006.01) ,A61K 9/16 (2006.01) ,A61K 31/155 (2006.01) ,A61K 31/7034 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (), e.g. guanidine (H2N-C(NH)-NH2), isourea (HNC(OH)NH2), isothiourea (HNC(SH)-NH2)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
Applicants:
한미약품 주식회사 HANMI PHARM. CO., LTD. [KR/KR]; 경기도 화성시 팔탄면 무하로 214 214, Muha-ro, Paltan-myeon, Hwaseong-si, Gyeonggi-do 18536, KR
Inventors:
조정현 CHO, Jung Hyun; KR
김형서 KIM, Hyung Seo; KR
권택관 KWON, Taek Kwan; KR
김용일 KIM, Yong Il; KR
Agent:
최은선 CHOI, Eun Sun; KR
Priority Data:
10-2017-012687829.09.2017KR
10-2018-007961409.07.2018KR
Title (EN) COMBINED PHARMACEUTICAL FORMULATION COMPRISING DAPAGLIFLOZIN L-PROLINE AND METFORMIN
(FR) FORMULATION PHARMACEUTIQUE COMBINÉE COMPRENANT DE LA DAPAGLIFLOZINE-L-PROLINE ET DE LA METFORMINE
(KO) 다파글리플로진 L-프롤린과 메트포르민을 포함하는 약제학적 복합제제
Abstract:
(EN) The present invention relates to a combined formulation comprising dapagliflozin L-proline and metformin both. A combined formulation according to the present invention is advantageous for long-term medication because the formulation exhibits not only improved storage stability and property stability and an excellent dissolution rate, but also is highly convenient for dosage. In addition, the combined formulation can be useful for prevention or treatment of diabetes, diabetes-related disease, or diabetic complications.
(FR) La présente invention concerne une formulation combinée comprenant de la dapagliflozine-L-proline et de la metformine. Une formulation combinée selon la présente invention est avantageuse pour un médicament à long terme parce que la formulation non seulement présente une stabilité au stockage et une stabilité de propriétés améliorées et une excellente vitesse de dissolution, mais est également très pratique pour le dosage. De plus, la formulation combinée peut être utile pour la prévention ou le traitement du diabète, d'une maladie liée au diabète ou de complications diabétiques.
(KO) 본 발명은 다파글리플로진 L-프롤린과 메트포르민을 동시에 포함하는 복합 제제에 관한 것으로, 본 발명의 복합 제제는 보관 안정성 및 성상 안정성이 개선되고 우수한 용출률을 나타낼 뿐만 아니라 복약 편의성이 높아 장기 복용에 용이하다. 또한, 상기 복합 제제는 당뇨병, 당뇨병 관련 질환 또는 당뇨병성 합병증의 예방 또는 치료에 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)