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1. (WO2019066252) COMPOSITION FOR TREATING FINE DUST-CAUSED SKIN CELL DAMAGE OR FOR INHIBITING ANTIBACTERIAL PEPTIDE, COMPRISING HIBISCUS SYRIACUS EXTRACT
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Pub. No.: WO/2019/066252 International Application No.: PCT/KR2018/009516
Publication Date: 04.04.2019 International Filing Date: 20.08.2018
IPC:
A61K 8/9789 (2017.01) ,A61K 36/185 (2006.01) ,A23L 33/105 (2016.01) ,A61Q 19/00 (2006.01) ,A61Q 17/00 (2006.01)
[IPC code unknown for A61K 8/9789]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
[IPC code unknown for A23L 33/105]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19
Preparations for care of the skin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
17
Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
Applicants:
(주)아모레퍼시픽 AMOREPACIFIC CORPORATION [KR/KR]; 서울시 용산구 한강대로 100 100, Hangang-daero, Yongsan-gu, Seoul 04386, KR
Inventors:
김형준 KIM, Hyoung-June; KR
이태룡 LEE, Tae Ryong; KR
Agent:
김순영 KIM, Sun-young; KR
Priority Data:
10-2017-012766529.09.2017KR
10-2017-012766729.09.2017KR
Title (EN) COMPOSITION FOR TREATING FINE DUST-CAUSED SKIN CELL DAMAGE OR FOR INHIBITING ANTIBACTERIAL PEPTIDE, COMPRISING HIBISCUS SYRIACUS EXTRACT
(FR) COMPOSITION POUR TRAITER DES LÉSIONS CELLULAIRES CUTANÉES PROVOQUÉES PAR LES POUSSIÈRES FINES OU POUR INHIBER UN PEPTIDE ANTIBACTÉRIEN, COMPRENANT UN EXTRAIT D'HIBISCUS SYRIACUS
(KO) 무궁화 추출물을 포함하는 미세먼지에 의한 피부 세포 손상 케어용 또는 항균성 펩티드 저해용 조성물
Abstract:
(EN) Disclosed in the present specification is a composition comprising a Hibiscus syriacus extract as an effective ingredient for treating fine dust-caused skin damage, wherein the expression of at least one selected from the group consisting of IL-36G (NM_019618), PTGS2(NM_000963), XDH(NM_000379), and S100A7(NM_002963), which are all genes having expression levels affected by fine dust in skin cells, is regulated to a normal level and for inhibiting an antibacterial peptide, wherein the expression of the antibacterial peptide S100A7(NM_002963) is regulated to a normal level. By using the composition for treating fine dust-caused skin damage and the composition for inhibiting an antibacterial peptide, gene expression changed by fine dust can return to a normal level to treat skin cell damage and the increased expression of the antibacterial peptide due to various causes can return to a normal level.
(FR) La présente invention concerne une composition comprenant un extrait d'Hibiscus syriacus en tant que principe actif pour traiter des lésions cutanées provoquées par les poussières fines, l'expression d'au moins un élément choisi dans le groupe constitué par IL-36 G (NM_019618), PTGS2 (NM _000963), XDH (NM_000379), et S100A7 (NM_002963), qui sont tous des gènes ayant des niveaux d'expression affectés par de les poussières fines dans des cellules cutanées, est régulée à un niveau normal et pour inhiber un peptide antibactérien, l'expression du peptide antibactérien S100A7 (NM_002963) étant régulée à un niveau normal. A l'aide de de la composition pour traiter des lésions cutanées provoquées par les poussières fines et de la composition pour inhiber un peptide antibactérien, l'expression génique modifiée par les poussières fines peut revenir à un niveau normal pour traiter une lésion de la cellule cutanée et l'expression accrue du peptide antibactérien due à diverses causes peut revenir à un niveau normal.
(KO) 본 명세서에는 무궁화 추출물을 유효성분으로 포함하는 조성물로서, 미세먼지에 의해 발현량이 영향을 받는 피부 세포 내 유전자인 IL-36G(NM_019618), PTGS2(NM_000963), XDH(NM_000379) 및 S100A7(NM_002963)로 이루어진 군에서 선택되는 하나 이상의 발현량을 정상 수준으로 조절하는 미세먼지에 의한 피부 손상 케어용 조성물 및 항균 펩티드인 S100A7(NM_002963)의 발현량을 정상 수준으로 조절하는 항균성 펩티드 저해용 조성물이 개시된다. 상기 미세먼지에 의한 피부 손상 케어용 조성물 및 항균성 펩티드 저해용 조성물을 이용함으로써, 미세먼지에 의해 변화되는 유전자 발현량을 정상 수준으로 되돌려 피부 세포의 손상을 케어할 수 있고, 다양한 원인에 의하여 증가한 항균성 펩티드의 발현량을 정상 수준으로 되돌릴 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)